NEUROBEHAVIORAL BASES OF EMOTION REGULATION AND DYSREGULATION IN ADOLESCENCE

青春期情绪调节和失调的神经行为基础

• 批准号: 8358228
• 负责人: Ned H Kalin
• 金额: $ 10.56万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358228
• 关键词: Adolescence; Adolescent; Amygdaloid structure; Animals; Anxiety; Behavioral; Data; Development; Funding; Grant; Image; Information Services; Library Services; Mental Depression; Molecular; National Center for Research Resources; Pathology; Primates; Principal Investigator; Psychopathology; Research; Research Infrastructure; Resources; Risk; Services; Source; Stress; United States National Institutes of Health; Wisconsin; base; cost; emotion regulation; neural circuit; neurobehavioral

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To understand the neural circuits and molecular mechanisms underlying the adolescent vulnerability to develop stress-induced psychopathology. The full title of this project is, "The Neurobehavioral Bases of Emotion Regulation and Dysregulation in Adolescence: Developmental Mechanisms Underlying the Risk to Develop Anxiety and Depression." Using microPET images, we defined groups based on high, middle and low amygdala reactivity during a behavioral challenge. These subjects have been further characterized behaviorally and physiologically both prior to and following relocation stress. These data will be used to define the parameters that engender vulnerability to psychopathology. This research used WNPRC Animal Services, Pathology, Operational Services, and Library & Information Services. PUBLICATIONS: None.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：了解精神分裂症的神经回路和分子机制。 青春期易患压力诱发的精神病态。 这个项目的全名是“青春期情绪调节和调节失调的神经行为基础：导致焦虑和抑郁风险的发育机制。” 使用microPET图像，我们根据行为挑战期间杏仁核的高、中和低反应性来定义组。在搬迁压力前后，这些受试者在行为和生理上都有了进一步的特征。这些数据将被用来定义导致精神病理学脆弱性的参数。 这项研究使用了WNPRC动物服务、病理学、运营服务和图书情报服务。 出版物： 没有。