Malt Liquor and Marijuana: Factors in Their Concurrent Versus Separate Use

我们感谢有机会重新关注这一应用，以实现与我们对年轻人使用男性酒（ML），其他酒精饮料和大麻（MJ）的理解相关的单一重要目标，所有这些都赋予经历负面后果的高风险，包括成瘾。 正如我们所指出的，对这一赠款申请的审查注意到了许多优点，总结如下。 a）麦芽酒的使用是一个未充分研究的主题，ML，其他酒精饮料和MJ的使用是重要的公共卫生问题。 2)拟议的研究具有很高的创新性，早该进行。 3)拟议的研究是基于一个明确的概念框架，并使用仔细（即，方法学上严格的）研究设计。 4)该应用程序写得很好，并响应以前的审查，包括评估所有酒精饮料的使用，而不仅仅是ML。 5)该研究团队此前曾成功招募了大量（> 600）经常饮用ML的人。 6)研究环境非常好，研究团队非常富有成效，由一位在酒精和药物领域处于领先地位的PI领导。 鉴于先前的评审员批准了本申请中提出的概念模型、设计和措施，本文件开始强调以下内容：1）选择一个可以在可用资金的2年内实现的具体目标，并简要概述该目标如何反映在研究设计和方法中; 2）提交一份详细的预算，总成本与作为早期申请的一部分提交的2年预算相似; 3）描述资助这项研究刺激布法罗大都市地区和国家经济的方式;以及4）说明两年期间要实现的时间表和里程碑。文件最后详细说明了拟议研究的意义。

We appreciate the opportunity to refocus this application to achieve a single important aim related to our understanding of young adults’ use of male liquor (ML), other alcoholic beverages, and marijuana (MJ), all of which confer high risks for experiencing negative consequences, including addiction. As we have noted, reviews of this grant application, have noted numerous strength, which are summarized below. a) Malt liquor use is an understudied topic and the use of ML, other alcoholic beverages, and MJ are important public health issues. 2) The proposed research is highly innovative and long overdue. 3) The proposed research is based on a well-articulated conceptual framework and uses careful (i.e., methodologically rigorous) study design. 4) The application is well-written and in response to previous reviews includes assessment of the use of all alcoholic beverages, not just ML. 5) This research team has previous been successful in recruiting a large (> 600) sample of regular ML drinkers. 6) The research environment is excellent and the research team is very productive and led by a PI who is a leader in the alcohol and drug field. Given the previous reviewers’ approval of the conceptual model, design, and measures proposed in this application, in this document begin by highlighting the following the following: 1) Selection of one specific aim that can be achieved within the 2 years of available funding and a brief overview of how that aim is reflected in the research design and methods; 2) Submission of a detailed budget similar in total costs to 2 years of the budget submitted as part of the earlier application; 3) Description of the ways in which funding this research stimulates the economy of the Buffalo metropolitan region and the nation; and 4) A description of timelines and milestones to be achieved during the 2-year period. The document ends with a detailed description of the significance of the proposed research.