LEUKOCYTE-DERIVED BIOMARKERS AS PREDICTORS OF RISK AND PROGRESSION IN ALZHEIMER'

白细胞衍生的生物标志物作为阿尔茨海默病风险和进展的预测因子

• 批准号: 7951079
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951079
• 关键词: Adult; Alzheimer' s Disease; Biological Markers; Blood; Blood Cells; Clinical Research; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Eye Color; Funding; Genes; Genetic Materials; Goals; Grant; Hair Color; Impaired cognition; Institution; Leukocytes; Memory; Neurodegenerative Disorders; Pattern; Research; Research Personnel; Resources; Risk; Source; Testing; Time; United States National Institutes of Health; age related cognitive disorder; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of the study is to determine if there are any differences in the patterns of genes and their products in blood between people with cognitive or neurodegenerative disorders and healthy adults. Genetic material determines things such as hair color, eye color, and other more complex traits. If the level and kinds of genetic material in blood cells are found to differ between people with and without age-related cognitive disorders, it may be possible to use these differences to help diagnose these conditions. Subjects will be given a variety of cognitive/memory testing and will have their blood drawn. They will be asked to return 3-5 times over 3 years to have their blood drawn again and memory tests completed. The study will examine the differences in the gene patterns between people with cognitive impairment and those without.

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