LEUKOCYTE-DERIVED BIOMARKERS AS PREDICTORS OF RISK AND PROGRESSION IN ALZHEIMER'

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的主要目标是确定患有认知或神经退行性疾病的人与健康成年人之间的基因及其产物模式是否存在任何差异。遗传物质决定了头发的颜色、眼睛的颜色和其他更复杂的特征。如果发现血细胞中遗传物质的水平和种类在有和没有与年龄相关的认知障碍的人之间存在差异，那么就有可能利用这些差异来帮助诊断这些疾病。 将对受试者进行各种认知/记忆测试，并抽取血液。 他们将被要求在3年内返回3-5次，再次抽血并完成记忆测试。 这项研究将检查有认知障碍的人和没有认知障碍的人之间基因模式的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of the study is to determine if there are any differences in the patterns of genes and their products in blood between people with cognitive or neurodegenerative disorders and healthy adults. Genetic material determines things such as hair color, eye color, and other more complex traits. If the level and kinds of genetic material in blood cells are found to differ between people with and without age-related cognitive disorders, it may be possible to use these differences to help diagnose these conditions. Subjects will be given a variety of cognitive/memory testing and will have their blood drawn. They will be asked to return 3-5 times over 3 years to have their blood drawn again and memory tests completed. The study will examine the differences in the gene patterns between people with cognitive impairment and those without.