LEUKOCYTE-DERIVED BIOMARKERS AS PREDICTORS OF RISK AND PROGRESSION IN ALZHEIMER'

白细胞衍生的生物标志物作为阿尔茨海默病风险和进展的预测因子

• 批准号: 7951079
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951079
• 关键词: Adult; Alzheimer' s Disease; Biological Markers; Blood; Blood Cells; Clinical Research; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Eye Color; Funding; Genes; Genetic Materials; Goals; Grant; Hair Color; Impaired cognition; Institution; Leukocytes; Memory; Neurodegenerative Disorders; Pattern; Research; Research Personnel; Resources; Risk; Source; Testing; Time; United States National Institutes of Health; age related cognitive disorder; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of the study is to determine if there are any differences in the patterns of genes and their products in blood between people with cognitive or neurodegenerative disorders and healthy adults. Genetic material determines things such as hair color, eye color, and other more complex traits. If the level and kinds of genetic material in blood cells are found to differ between people with and without age-related cognitive disorders, it may be possible to use these differences to help diagnose these conditions. Subjects will be given a variety of cognitive/memory testing and will have their blood drawn. They will be asked to return 3-5 times over 3 years to have their blood drawn again and memory tests completed. The study will examine the differences in the gene patterns between people with cognitive impairment and those without.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该研究的主要目的是确定认知或神经退行性疾病和健康成年人之间的基因模式及其产物的血液模式及其产物的差异。遗传材料确定了诸如头发颜色，眼睛颜色和其他更复杂的特征之类的事物。如果发现血细胞中的遗传物质水平和种类在患有和没有年龄相关的认知障碍的人之间有所不同，则可能有可能使用这些差异来帮助诊断这些疾病。 受试者将获得各种认知/记忆测试，并将其抽血。 他们将被要求在3年内返回3-5次，以再次抽血，并完成记忆测试。 该研究将检查认知障碍者与没有认知障碍者之间的基因模式差异。