Core B-Clinical Core

核心 B-临床核心

• 批准号: 9922101
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 61.75万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922101
• 关键词: Alzheimer associated neurodegeneration; Alzheimer' s Disease; Amyloid; Ancillary Study; Asian Americans; Asians; Autopsy; Biochemical; Biological Markers; Blood; Blood Vessels; Brain; California; Cardiovascular system; Cell Line; Cerebrospinal Fluid; Cessation of life; Chinese American; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical assessments; Cognitive; Collaborations; Collection; Consent; Data; Data Set; Dementia; Deposition; Diagnostic; Disease; Ecosystem; Education; Enrollment; Ethnic Origin; Female; Fibroblasts; Funding; Generations; Genetic; Hispanics; Home environment; Image; Impaired cognition; Individual; Investigation; Link; Longevity; Longitudinal cohort; Magnetic Resonance Imaging; Methodology; Minority; Mission; Molecular; Neurocognitive; Neurologic; Participant; Peripheral Blood Mononuclear Cell; Population; Positron-Emission Tomography; Procedures; Punch Biopsy; Questionnaires; Race; Randomized; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Risk; Role; Sampling; Skin; Spinal Puncture; Symptoms; System; Telephone; Telephone Interviews; Tissue Donations; Training; Training and Education; Translational Research; Universities; clinical trial participant; cognitive testing; cohort; data management; demented; disorder risk; education research; follow-up; genetic analysis; improved; inclusion criteria; induced pluripotent stem cell; innovation; mild cognitive impairment; neuroimaging marker; next generation; novel; outreach; pre-clinical; programs; recruit; retention rate; stem cells; tau Proteins; tissue biomarkers

Core B: Clinical Core Project Summary/Abstract The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS, participants and their study partners complete questionnaires and assessments unique to our ADRC, and voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify, quantify, and validate factors that influence the risk of AD across the lifespan.”!

核心B：临床核心 项目总结/摘要 UCI ADRC临床核心招募，表征和跟踪一组认知障碍的个体， 未受损、认知受损或痴呆，每个人都完成了统一数据集（UDS）， 身体和神经系统检查以及一系列神经认知评估。除了这个UDS， 参与者和他们的研究伙伴完成我们ADRC独有的问卷和评估， 自愿提供各种组织和生物标志物评估，包括遗传分析、体积分析、 成像、脑脊液分析和用于产生诱导多能干细胞的成纤维细胞捐赠 细胞（iPSC）。总体而言，我们目前的330名积极参与者中有292人捐献了成纤维细胞或外周血 我们使用单个核细胞（PBMC），其已被我们的iPSC Core用于产生192个iPSC系。最 参与者同意在尸检时捐献大脑，我们的尸检成功率很高 确认死亡。我们的UDS队列目前包括330名活跃参与者。在这群人中，60%是 三分之一是非白人或西班牙裔。19%的人精神错乱，18%的人 轻度认知障碍（MCI）的诊断标准，大多数（60%）不符合MCI的诊断标准， 痴呆我们的总体保留率非常高，高于ADRC系统的中位数。大多数UDS 参与者参加了外部资助的辅助研究， 神经影像生物标记物研究。为了支持ADRC调查人员日益增长的需求，包括新的 在分子和血管生物标志物的研究中，我们将使该UDS队列增长至稳态n=400， 强调招募能够支持UCI ADRC主题的新研究的个人， 量化和验证影响整个生命周期中AD风险的因素。"