Clinical and Pathological Studies in the Oldest Old

最古老的临床和病理学研究

• 批准号: 6907727
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 12.6万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6907727
• 关键词: aging; antioxidants; brain; clinical research; cognition; dementia; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; functional ability; gene environment interaction; human mortality; human subject; human very old age (85+); inflammation; longevity; longitudinal human study; mental health epidemiology; neuropathology; nonsteroidal antiinflammatory agent; oxidative stress; postmortem; psychological aspect of aging; questionnaires

DESCRIPTION (provided by applicant): In the next two decades, the number of Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. The goals of this application are to investigate clinical, genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatory drugs(NSAIDS). Our central hypothesis is that oxidative damage and inflammation in the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improve the health of the oldest old. Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatory markers, and plaque and tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatory compounds. The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.

描述（由申请人提供）：在未来二十年，90岁及以上的美国人数量将增加近一倍，超过300万人。由于以前的研究很少有90岁以上的受试者，因此对这些先驱者或与这一群体的成功衰老和健康相关的因素知之甚少。 该应用程序的目标是调查与极端老年相关的临床，遗传和病理因素。我们回顾了1981年发起的休闲世界队列研究的调查。20多年来，队列成员（N = 13，979）提供了病史和生活方式信息，包括疾病、家族史、运动、社会活动和药物使用，如抗氧化剂和非甾体抗炎药（NSAIDS）。 我们的中心假设是，大脑中的氧化损伤和炎症导致衰老，疾病和死亡，摄入抗氧化剂和NSAIDS将减缓认知能力下降，改善老年人的健康状况。 我们的具体目标是：（1）检查4,682名达到90岁的队列成员与6734名未达到90岁的队列成员中与长寿相关的因素，（2）确定1,644名10岁和11岁的生活队列成员中痴呆症的患病率，发病率和风险因素，（3）进行纵向随访，以测量这些年龄最大的老年受试者的认知和功能下降率，和（4）完成我们对健康和疾病中脑老化的临床病理学相关性的研究，重点是氧化损伤，炎症标志物，以及斑块和缠结病理学，因为它涉及临床状态和抗氧化剂和抗炎化合物的先前使用。 休闲世界队列研究提供了一个独特的人口样本，研究遗传和环境因素与长寿和成功的老龄化在最古老的老人。有了大量的承诺对象和20年的前瞻性数据，我们提出的调查可以大大有助于我们社会中最古老的成员的认知，功能能力和大脑病理学的理解。