Clinical and Pathological Studies in the Oldest Old

最古老的临床和病理学研究

• 批准号: 7496763
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 20.39万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7496763
• 关键词: Activities of Daily Living; Age; Age-Years; Aged, 80 and over; Aging; Alleles; Alzheimer' s Disease; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Apolipoprotein E; Ascorbic Acid; Brain; Cerebrum; Cessation of life; Characteristics; Cholesterol; Clinical; Cognition; Cognitive; Cohort Studies; Commit; Condition; Data; Dementia; Diet; Disease; Drops; Drug usage; Environmental Risk Factor; Epidemiology; Exercise; Family history of; Folate; Frequencies; Genetic; Genotype; Goals; Habits; Health; Homocysteine; Homocystine; Ibuprofen; Impaired cognition; Incidence; Individual; Injury; Intake; Investigation; Life; Life Style; Lipids; Longevity; Lower Extremity; Measures; Medical History; Neurofibrillary Tangles; Numbers; Nutrient; Oxidative Stress; Pathology; Performance; Pharmaceutical Preparations; Population; Prevalence; Proteins; Range; Rate; Reporting; Risk; Risk Factors; Sampling Studies; Serum Folate Level; Societies; Vitamins; aged; aging brain; cognitive function; cohort; experience; falls; follow-up; functional decline; member; mortality; neuroinflammation; normal aging; prospective; social

CLINICAL ANDPATHOLOGICAL STUDIES IN THE OLDEST OLD In the next two decades, the numberof Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. The goals of this proposal are to investigate clinical,genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatorydrugs (NSAIDS). Our central hypothesis is that oxidative damage and inflammationin the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improvethe health of the oldest old. Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatorymarkers, and plaqueand tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatorycompounds. The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.

高龄老年人的临床和药理学研究 在接下来的20年里，90岁及以上的美国人的数量将几乎翻一番，超过300万人。 因为以前的研究几乎没有，如果有的话，超过90岁的受试者，对这些先驱者或关于他们的了解很少。 这一组中与成功老龄化和健康相关的因素。 这项建议的目标是调查与极端老年相关的临床、遗传和病理因素。 我们将我们的调查与始于1981年的休闲世界队列研究相结合。20多年来，队列 成员(N=13,979)提供了病史和生活方式信息，包括疾病情况、家庭 病史、锻炼、社交活动和用药情况，如抗氧化剂和非类固醇消炎药 (非甾体抗炎药)。 我们的中心假设是大脑中的氧化损伤和炎症会导致衰老、疾病和死亡 抗氧化剂和非甾体抗炎药的摄入将减缓认知能力的下降，并改善最年长老年人的健康。 我们的具体目标是：(1)在4682名达到年龄的队列成员中检查与长寿相关的因素 (2)在1,644人中确定痴呆症的患病率、发病率和危险因素 生活在十岁和十一岁的队列成员，(3)进行纵向跟踪，以衡量 这些年龄最大的老年受试者的认知和功能衰退，以及(4)完成我们的临床调查 健康和疾病中大脑老化的病理相关性，重点是大脑测量的相关性 氧化损伤、炎症标志物、斑块和纠缠病理与临床状态和既往用药有关 抗氧化剂和消炎药的混合物。 休闲世界队列研究为遗传和环境研究提供了一个独特的人群样本 与高龄老年人长寿和成功老龄化相关的因素。拥有一大批致力于 受试者和20年的前瞻性数据，我们建议的调查可以大大有助于理解 我们社会中年龄最大的成员的认知、功能能力和脑部病理。