Clinical and Pathological Studies in the Oldest Old

最古老的临床和病理学研究

• 批准号: 7496763
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 20.39万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7496763
• 关键词: Activities of Daily Living; Age; Age-Years; Aged, 80 and over; Aging; Alleles; Alzheimer' s Disease; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Apolipoprotein E; Ascorbic Acid; Brain; Cerebrum; Cessation of life; Characteristics; Cholesterol; Clinical; Cognition; Cognitive; Cohort Studies; Commit; Condition; Data; Dementia; Diet; Disease; Drops; Drug usage; Environmental Risk Factor; Epidemiology; Exercise; Family history of; Folate; Frequencies; Genetic; Genotype; Goals; Habits; Health; Homocysteine; Homocystine; Ibuprofen; Impaired cognition; Incidence; Individual; Injury; Intake; Investigation; Life; Life Style; Lipids; Longevity; Lower Extremity; Measures; Medical History; Neurofibrillary Tangles; Numbers; Nutrient; Oxidative Stress; Pathology; Performance; Pharmaceutical Preparations; Population; Prevalence; Proteins; Range; Rate; Reporting; Risk; Risk Factors; Sampling Studies; Serum Folate Level; Societies; Vitamins; aged; aging brain; cognitive function; cohort; experience; falls; follow-up; functional decline; member; mortality; neuroinflammation; normal aging; prospective; social

CLINICAL ANDPATHOLOGICAL STUDIES IN THE OLDEST OLD In the next two decades, the numberof Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. The goals of this proposal are to investigate clinical,genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatorydrugs (NSAIDS). Our central hypothesis is that oxidative damage and inflammationin the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improvethe health of the oldest old. Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatorymarkers, and plaqueand tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatorycompounds. The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.

最古老的临床和人行为研究 在接下来的二十年中，90岁及以上的美国人人数将几乎翻一番，超过300万人。 由于以前的研究很少（如果有的话）90岁以上的受试者，对这些开拓者或大约几乎不知道 与该组成功衰老和健康相关的因素。 该提案的目标是研究与极端年龄相关的临床，遗传和病理因素。 我们对1981年启动的休闲世界队列研究进行了叠加。 成员（n = 13,979）提供了病史和生活方式信息，包括病态状况，家庭 历史，运动，社交活动和药物使用，例如抗氧化剂和非甾体类抗炎药 （NSAIDS）。 我们的中心假设是，大脑在大脑中氧化损伤和炎症导致衰老，疾病和死亡，以及 对抗氧化剂和非杀伤性NSAID的摄入将减缓最古老的老年人的认知能力下降并改善健康状况。 我们的具体目的是：（1）检查与年龄的4,682名队列成员中与寿命相关的因素 90与没有的6734相比，（2）确定1,644的患病率，发病率和危险因素 活着的队列成员在十年和十一几十年中，（3）进行纵向随访，以衡量率 这些最古老的旧受试者的认知和功能下降，以及（4）完成我们的临床调查 健康和疾病中大脑衰老的病理相关性，重点是 氧化损伤，炎症标志物和plaqueand Tangle病理学与临床状况和先前使用有关 抗氧化剂和抗炎作用。 休闲世界队列研究为遗传和环境研究提供了独特的人群样本 最古老的老年人与寿命和成功衰老有关的因素。有大量的奉献 受试者和20年的潜在数据，我们的拟议调查可以为理解做出很大的贡献 我们社会最古老的成员的认知，功能能力和脑病理学。