Clinical and Pathological Studies in the Oldest Old

最古老的临床和病理学研究

• 批准号: 6934497
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 119.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6934497
• 关键词: aging; antioxidants; brain; clinical research; cognition; dementia; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; functional ability; gene environment interaction; human mortality; human subject; human very old age (85+); inflammation; longevity; longitudinal human study; mental health epidemiology; neuropathology; nonsteroidal antiinflammatory agent; oxidative stress; postmortem; psychological aspect of aging; questionnaires

DESCRIPTION (provided by applicant): In the next two decades, the number of Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. The goals of this application are to investigate clinical, genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatory drugs(NSAIDS). Our central hypothesis is that oxidative damage and inflammation in the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improve the health of the oldest old. Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatory markers, and plaque and tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatory compounds. The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.

描述（由申请人提供）：在接下来的二十年里，美国90岁及以上的人数将增加近一倍，达到300多万人。因为之前的研究只有很少（如果有的话）90岁以上的受试者，所以对这些先驱者或与这一群体成功衰老和健康相关的因素知之甚少。