SUNLIGHT, NUTRITION, SKIN, AND HUMAN ANCESTRY RELATED TO VITAMIN D EXPOSURE AND

与维生素 D 暴露相关的阳光、营养、皮肤和人类血统

• 批准号: 7951354
• 负责人: Robin Taylor Wilson
• 金额: $ 8.27万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951354
• 关键词: African American; Age; Area; Blood; CYP3A4 gene; Caucasians; Caucasoid Race; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; DNA; Funding; Genes; Genetic; Genotype; Grant; Human; Incidence; Institution; Lymphocyte; Malignant Neoplasms; Measurement; Medial; Melanins; Mixed Function Oxygenases; Participant; Pilot Projects; Play; Prevalence; Research; Research Personnel; Resources; Response Elements; Role; Serum; Serum Calcium Level; Side; Single Nucleotide Polymorphism; Skin; Source; Spottings; Students; Sun Exposure; Sunlight; Time; United States National Institutes of Health; Upper arm; Variant; Vitamin D; Vitamin D3 Receptor; cancer health disparity; indexing; nutrition; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer health disparities among African Americans are increasing. Vitamin D is suspected to play a role in several cancers and other chronic conditions with a higher incidence among African Americans. These studies are aimed at understanding if this disparity is due to prevalence of single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) or VDR response elements (VDREs). Differences in serum vitamin D between African American and Caucasian participants will be associated with VDR genotype (short/short, short/long, long/long) and polymorphic variants occurring within VDRE located in VDR, CYP24A1 (24-hydroxylase), and CYP3A4. This study will be conducted with 154 healthy African American and 154 healthy Caucasian Penn State student participants during non-Summer months. (A pilot study was conducted previously, thus an additional 104 African American and 104 Caucasian participants are necessary.) Association between the serum vitamin D level and genotypes will be evaluated adjusting for age, sex, genetic ancestry, skin reflectance (melanin index), sunlight exposure and serum calcium levels will be determined. The SNPs will be determined in blood spots and lymphocyte DNA by re-sequencing of areas of the genes and comparing to the reference sequences. A DermaSpectrometer (CyberDerm, Media, Pa., USA) will be used three times on the upper inner side (medial aspect) of each arm with melanin index measurements averaged.

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