CLINICAL CENTER FOR THE OSTEOARTHRITIS (OA) INITIATIVE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 骨关节炎倡议（OAI）是一项多中心观察性队列研究，旨在确定膝关节骨关节炎发生和/或进展的生物标志物。年龄在45-79岁之间的男性和女性是招生对象。有兴趣的人士会由一名受过训练的访问员进行电话访问。如果认为合格，则安排筛选访视。如果根据筛选访视时获得的X线片合格，则计划在6周内进行入组访视。预计每例入组受试者将完成4次年度随访临床访视，与入组访视相当。 每个临床中心（有4个，包括巴尔的摩）预计招募1,250例受试者;对于巴尔的摩，该数量将在马里兰州大学巴尔的摩研究中心和约翰霍普金斯Bayview研究中心之间分配。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Osteoarthritis Initiative (OAI) is a multicenter observational cohort study designed to identify biomarkers for the development and/or progression of osteoarthritis of the knee. Men and women aged 45-79 years of age are targeted for enrollment. Interested parties are interviewed over the telephone by a trained interviewer. If deemed eligible, a screening visit is scheduled. If eligible based on the radiographs obtained at the screening visit, an enrollment visit is scheduled within 6 weeks. Each enrolled participant is expected to complete four annual follow-up clinical visits which are comparable to the enrollment visit. Each clinical center (there are 4, including Baltimore) is expected to recruit 1,250 subjects; for Baltimore, this number will be split between the University of Maryland Baltimore site and the Johns Hopkins Bayview site.