CLINICAL CENTER FOR THE OSTEOARTHRITIS (OA) INITIATIVE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 骨关节炎倡议(OAI)是一项多中心观察性队列研究，旨在确定膝骨性关节炎发生和/或进展的生物标志物。年龄在45岁至79岁之间的男性和女性是注册的目标。感兴趣的人通过电话接受训练有素的面试者的采访。如果被认为符合条件，将安排筛查访问。如果根据筛查访问获得的X光照片符合条件，则计划在6周内进行登记访问。每个登记的参与者预计要完成四次与登记访问相当的年度临床随访。每个临床中心(有4个，包括巴尔的摩)预计将招收1250名受试者；对于巴尔的摩，这个数字将在马里兰大学巴尔的摩分校和约翰霍普金斯大学贝维尤分校。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Osteoarthritis Initiative (OAI) is a multicenter observational cohort study designed to identify biomarkers for the development and/or progression of osteoarthritis of the knee. Men and women aged 45-79 years of age are targeted for enrollment. Interested parties are interviewed over the telephone by a trained interviewer. If deemed eligible, a screening visit is scheduled. If eligible based on the radiographs obtained at the screening visit, an enrollment visit is scheduled within 6 weeks. Each enrolled participant is expected to complete four annual follow-up clinical visits which are comparable to the enrollment visit. Each clinical center (there are 4, including Baltimore) is expected to recruit 1,250 subjects; for Baltimore, this number will be split between the University of Maryland Baltimore site and the Johns Hopkins Bayview site.