Clinical Centers for the Osteoarthritis Initiative
骨关节炎倡议临床中心
基本信息
- 批准号:8340966
- 负责人:
- 金额:$ 100.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-07-15 至 2012-07-14
- 项目状态:已结题
- 来源:
- 关键词:AdultAgeArthralgiaArthritisBiological MarkersBloodClinicalCollectionContractsDataData Coordinating CenterDegenerative polyarthritisDevelopmentEnrollmentGait abnormalityGeneral PopulationHandHealthIndividualKneeKnee InjuriesKnee OsteoarthritisLeadMagnetic Resonance ImagingMedicalMinorityObesityObservational StudyOperative Surgical ProceduresPainParticipantPhysical ExaminationPopulationQuestionnairesRecruitment ActivityResearchResearch PersonnelRisk FactorsRoentgen RaysScreening procedureSymptomsUrineVisitWomandisabilityfollow-uphigh riskknee painpreventresearch studytrend
项目摘要
Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. The purpose of this study is to examine people who have knee OA or are at high risk for knee OA; information will be used to better understand how to prevent and treat knee OA Knee OA causes more health problems and medical expenses that any other form of arthritis. Symptoms of OA can range from stiffness and mild pain to severe joint pain and even disability. Previous research has shown that certain factors, such as knee pain, prior knee injury or knee surgery, OA of the hand, or obesity, may lead to knee OA. The OAI is a multicenter, observational study of knee OA that will collect information on potential biomarkers for OA and trends in OA onset and progression. The OAI will recruit and follow participants who have knee OA or are at high risk for developing knee OA for at least a four-year period at one of four clinical centers. Blood and urine collection, magnetic resonance imaging (MRI), and X-rays will be completed at each of four annual follow-up visits. A questionnaire and physical examination at screening will assess for risk factors for the development and progression of knee OA. Levels of knee pain and physical disability will be assessed at study start and at each of the follow-up visits by questionnaire and examination.
膝骨关节炎(OA)是成人残疾的最常见原因。 “骨关节炎倡议(OAI):膝关节健康研究”是一项全国性研究,将帮助研究人员收集更多有关关节炎症状出现之前或骨关节炎恶化之前发生的身体变化的信息。本研究的目的是检查患有膝骨关节炎或膝骨关节炎高风险的人;信息将用于更好地了解如何预防和治疗膝关节骨关节炎 与任何其他形式的关节炎相比,膝关节骨关节炎会导致更多的健康问题和医疗费用。骨关节炎的症状范围从僵硬和轻度疼痛到严重的关节疼痛甚至残疾。先前的研究表明,某些因素,例如膝盖疼痛、先前的膝盖受伤或膝盖手术、手部骨关节炎或肥胖,可能会导致膝关节骨关节炎。 OAI 是一项针对膝关节 OA 的多中心观察性研究,将收集 OA 潜在生物标志物以及 OA 发病和进展趋势的信息。 OAI 将在四个临床中心之一招募并跟踪患有膝骨关节炎或膝骨关节炎高风险的参与者至少四年。每年四次随访时,每次都会完成血液和尿液采集、磁共振成像 (MRI) 和 X 射线检查。筛选时的问卷调查和体检将评估膝关节骨关节炎发生和进展的危险因素。将在研究开始时以及每次随访时通过问卷和检查来评估膝盖疼痛和身体残疾的程度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marc C. Hochberg其他文献
Preferences in the management of osteoarthritis of the hip and knee: results of a survey of community-based rheumatologists in the United States.
髋关节和膝关节骨关节炎的治疗偏好:美国社区风湿病学家的调查结果。
- DOI:
- 发表时间:
1996 - 期刊:
- 影响因子:0
- 作者:
Marc C. Hochberg;Donna L. Perlmutter;James I. Hudson;R. D. Altman - 通讯作者:
R. D. Altman
016 - ASSOCIATION OF MAGNETIC RESONANCE IMAGING BIOMARKERS WITH WOMAC SCORES AND SUBSEQUENT KNEE ARTHROPLASTY
016 - 磁共振成像生物标志物与 WOMAC 评分及随后膝关节置换术的关联
- DOI:
10.1016/j.joca.2025.02.020 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:9.000
- 作者:
Stephanie Jo;Ronnie Sebro;Laurence S. Magder;Linda Chang;Marc C. Hochberg;Braxton D. Mitchell - 通讯作者:
Braxton D. Mitchell
Mortality in osteoarthritis.
- DOI:
- 发表时间:
2008-09 - 期刊:
- 影响因子:3.7
- 作者:
Marc C. Hochberg - 通讯作者:
Marc C. Hochberg
The accuracy of self-report of physician diagnosed rheumatoid arthritis in moderately to severely disabled older women. Women's Health and Aging Collaborative Research Group.
医生诊断中度至重度残疾老年女性类风湿性关节炎的自我报告的准确性。
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:3.9
- 作者:
Shari Ling;Linda P. Fried;Elizabeth Garrett;Rosemarie Hirsch;J. M. Guralnik;Marc C. Hochberg - 通讯作者:
Marc C. Hochberg
Reliability of grading scales for individual radiographic features of osteoarthritis of the knee. The Baltimore longitudinal study of aging atlas of knee osteoarthritis.
膝骨关节炎个体放射学特征分级量表的可靠性。
- DOI:
10.1097/00004424-199306000-00005 - 发表时间:
1993 - 期刊:
- 影响因子:6.7
- 作者:
W. W. Scott;M. Lethbridge;R. Reichle;Fredrick M. Wigley;Jordan D. Tobin;Marc C. Hochberg - 通讯作者:
Marc C. Hochberg
Marc C. Hochberg的其他文献
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{{ truncateString('Marc C. Hochberg', 18)}}的其他基金
CLINICAL CENTER FOR THE OSTEOARTHRITIS (OA) INITIATIVE
骨关节炎 (OA) 倡议临床中心
- 批准号:
7951142 - 财政年份:2009
- 资助金额:
$ 100.41万 - 项目类别:
CLINICAL CENTER FOR THE OSTEOARTHRITIS (OA) INITIATIVE
骨关节炎 (OA) 倡议临床中心
- 批准号:
7608129 - 财政年份:2007
- 资助金额:
$ 100.41万 - 项目类别:
CLINICAL CENTER FOR THE OSTEOARTHRITIS (OA) INITIATIVE
骨关节炎 (OA) 倡议临床中心
- 批准号:
7203310 - 财政年份:2005
- 资助金额:
$ 100.41万 - 项目类别:
Clinical Centers for the Osteoarthritis Initiative
骨关节炎倡议临床中心
- 批准号:
7942212 - 财政年份:2002
- 资助金额:
$ 100.41万 - 项目类别:
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE
骨关节炎倡议临床中心
- 批准号:
7543468 - 财政年份:2002
- 资助金额:
$ 100.41万 - 项目类别:
Clinical Centers for the Osteoarthritis Initiative
骨关节炎倡议临床中心
- 批准号:
8008921 - 财政年份:2002
- 资助金额:
$ 100.41万 - 项目类别:
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