INSULIN DEGRADING ENZYME IN COMPLEX WITH THE NOVEL SUBSTRATES

胰岛素降解酶与新型底物的复合物

基本信息

  • 批准号:
    7956828
  • 负责人:
  • 金额:
    $ 2.36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-08-01 至 2010-07-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The insulin-degrading enzyme (IDE) is a 110 kDa zinc metallo-endoprotease that degrades many physiologically relevant substrates such as peptide hormones (insulin, insulin-like growth factor-II, glucagon, atrial natriuretic factor, and beta-endophin), amyloid β peptide, and tumor growth factor-alpha. Functional studies have shown that IDE plays important roles in the regulation of developmental and metabolic processes as well as in the development of type 2 diabetes mellitus and Alzheimer?s disease. Thus, IDE is a promising therapeutic target for several human diseases. We have solved the structures of IDE alone and catalytically inactive IDE in complex with several biologically relevant substrates including insulin, amyloid β, glucagon, and bradykinin. Our structures reveal how size, charge distribution, and the propensity of unfolding of IDE substrates could contribute their selective cleavages by IDE. We hypothesize that the list of IDE substrates is incomplete and our knowledge in the interaction of IDE with IDE substrates can be used to identify the novel substrates. Using this strategy, we have identified several novel IDE substrates and would propose to solve the structures of IDE with these substrates.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
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专利数量(0)

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WEI-JEN TANG其他文献

WEI-JEN TANG的其他文献

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{{ truncateString('WEI-JEN TANG', 18)}}的其他基金

Integrative structural analysis of human insulin degrading enzyme
人胰岛素降解酶的整体结构分析
  • 批准号:
    10684300
  • 财政年份:
    2017
  • 资助金额:
    $ 2.36万
  • 项目类别:
Integrative structural analysis of human insulin degrading enzyme
人胰岛素降解酶的整体结构分析
  • 批准号:
    10810459
  • 财政年份:
    2017
  • 资助金额:
    $ 2.36万
  • 项目类别:
Integrative structural analysis of human insulin degrading enzyme
人胰岛素降解酶的整体结构分析
  • 批准号:
    10490454
  • 财政年份:
    2017
  • 资助金额:
    $ 2.36万
  • 项目类别:
Integrative structural analysis of human insulin degrading enzyme
人胰岛素降解酶的整体结构分析
  • 批准号:
    10367488
  • 财政年份:
    2017
  • 资助金额:
    $ 2.36万
  • 项目类别:
ANALYZE THE COMPLEX PROTEIN ASSEMBLY USING SAXS
使用 SAXS 分析复杂的蛋白质组装
  • 批准号:
    8361305
  • 财政年份:
    2011
  • 资助金额:
    $ 2.36万
  • 项目类别:
SAXS OF THE COMPLEX OF ANTHRAX TOXINS AND HUMAN INSULIN DEGRADING ENZYME
炭疽毒素与人胰岛素降解酶复合物的SAXS
  • 批准号:
    8168652
  • 财政年份:
    2010
  • 资助金额:
    $ 2.36万
  • 项目类别:
Regulation and Catalysis of Human Insulin Degrading Enzyme
人胰岛素降解酶的调控与催化
  • 批准号:
    7898366
  • 财政年份:
    2009
  • 资助金额:
    $ 2.36万
  • 项目类别:
PRESEQUENCE PEPTIDASE IN NATIVE OR COMPLEXED WITH SUBSTRATES
天然或与底物复合的前序列肽酶
  • 批准号:
    7956813
  • 财政年份:
    2009
  • 资助金额:
    $ 2.36万
  • 项目类别:
INSULIN DEGRADING ENZYME IN COMPLEX WITH NATRIURETIC PEPTIDES
胰岛素降解酶与钠尿肽的复合物
  • 批准号:
    7956832
  • 财政年份:
    2009
  • 资助金额:
    $ 2.36万
  • 项目类别:
HUMAN INSULIN DEGRADING ENZYME-INHIBITOR COMPLEX
人胰岛素降解酶抑制剂复合物
  • 批准号:
    7601588
  • 财政年份:
    2007
  • 资助金额:
    $ 2.36万
  • 项目类别:

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A Possible Association Between Insulin and Alzheimer?s Disease: Examining the Consequences of Altered Insulin Signalling on the Expression of Human Amyloid-Beta in Caenorhabditis elegans
胰岛素与阿尔茨海默氏病之间的可能关联:检查胰岛素信号改变对秀丽隐杆线虫中人类β淀粉样蛋白表达的影响
  • 批准号:
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β 淀粉样蛋白的硝化 阿尔茨海默病
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  • 批准号:
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脑淀粉样蛋白在唐氏综合症认知、脑萎缩和阿尔茨海默病中作用的研究
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