MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多项研究一直证明精神分裂症(SP)患者存在感觉加工缺陷。其中一个缺陷是感觉门控不佳，与健康的正常志愿者(HNV)相比，SP中对两个快速呈现的刺激中的第二个的电生理反应增强。这种影响通常以比较第一(S1)和第二(S2)刺激(S2/S1*100)的响应幅度的门控比来报告。感觉门控不良的特点是选择性注意缺陷和/或记忆痕迹的形成，是典型的SP患者认知和随后的社会功能障碍的有用的生物标志物。虽然动物和侵袭性人类研究一直认为听觉皮质、前额叶皮质和海马体参与了感觉门控反应的调节，但在非侵入性成像中，这些结构的局部激活并不总是被报道。此外，这种缺陷主要是通过脑电(EEG)和脑磁图(MEG)等电生理技术记录下来的。到目前为止，还没有一项功能磁共振成像(FMRI)研究使用传统的门控范式来表征精神分裂症门控缺陷的血流动力学标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple lines of research have consistently documented sensory processing deficits in patients with schizophrenia (SP). One such deficit is poor sensory gating, in which there is an increased electrophysiological response for the second of two rapidly presented stimuli in SP compared to healthy normal volunteers (HNV). This effect is typically reported in terms of a gating ratio comparing the amplitude of the response for both the first (S1) and second (S2) stimulus (S2/S1*100). Poor sensory gating has been characterized as both a deficit in selective attention and/or in the formation of memory traces, and is a useful bio-marker of the cognitive and subsequent social dysfunction that is typically observed in SP. Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating response, localized activation in these structures has not always been reported during non-invasive imaging modalities. Moreover, this deficit has been primarily been documented using electrophysiological techniques such as electroencephalography (EEG) and magnetoencephalography (MEG). To date, there has not been a single functional magnetic resonance imaging (FMRI) study that has characterized hemodynamic markers of the gating deficit in schizophrenia using the traditional gating paradigm.