MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA
精神分裂症感觉门控缺陷的多模态成像
基本信息
- 批准号:7960404
- 负责人:
- 金额:$ 26.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2010-06-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAuditory areaCognitiveComputer Retrieval of Information on Scientific Projects DatabaseElectroencephalographyFunctional Magnetic Resonance ImagingFunctional disorderFundingGrantHippocampus (Brain)HumanInstitutionMagnetoencephalographyMediatingMemoryMultimodal ImagingPatientsPrefrontal CortexReportingResearchResearch PersonnelResourcesSchizophreniaSensory ProcessSourceStimulusStructureTechniquesUnited States National Institutes of Healthhemodynamicsimaging modalityneuroimagingneuromechanismresponseselective attentionsensory gatingsocialtoolvolunteer
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Multiple lines of research have consistently documented sensory processing deficits in patients with schizophrenia (SP). One such deficit is poor sensory gating, in which there is an increased electrophysiological response for the second of two rapidly presented stimuli in SP compared to healthy normal volunteers (HNV). This effect is typically reported in terms of a gating ratio comparing the amplitude of the response for both the first (S1) and second (S2) stimulus (S2/S1*100). Poor sensory gating has been characterized as both a deficit in selective attention and/or in the formation of memory traces, and is a useful bio-marker of the cognitive and subsequent social dysfunction that is typically observed in SP. Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating response, localized activation in these structures has not always been reported during non-invasive imaging modalities. Moreover, this deficit has been primarily been documented using electrophysiological techniques such as electroencephalography (EEG) and magnetoencephalography (MEG). To date, there has not been a single functional magnetic resonance imaging (FMRI) study that has characterized hemodynamic markers of the gating deficit in schizophrenia using the traditional gating paradigm.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
多线研究一致记录了精神分裂症(SP)患者的感觉处理缺陷。一个这样的缺陷是差的感觉门控,其中与健康正常志愿者(HNV)相比,SP中的两个快速呈现的刺激中的第二个的电生理反应增加。这种效应通常以门控比的形式报告,门控比比较第一(S1)和第二(S2)刺激的响应幅度(S2/S1*100)。差的感觉门控被表征为选择性注意和/或记忆痕迹形成的缺陷,并且是通常在SP中观察到的认知和随后的社会功能障碍的有用生物标志物。尽管动物和侵入性人类研究一直涉及听觉皮层、前额皮质和海马介导感觉门控反应,在这些结构中的局部激活在非侵入性成像模式中并不总是被报道。此外,这种缺陷主要是使用电生理技术,如脑电图(EEG)和脑磁图(MEG)记录的。迄今为止,还没有一个单一的功能磁共振成像(FMRI)的研究,其特点是血流动力学标记的门控缺陷,精神分裂症使用传统的门控范例。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrew Robert Mayer其他文献
Andrew Robert Mayer的其他文献
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{{ truncateString('Andrew Robert Mayer', 18)}}的其他基金
Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)
III 期 COBRE:神经精神疾病 (MIND) 的多模态成像
- 批准号:
10324137 - 财政年份:2018
- 资助金额:
$ 26.69万 - 项目类别:
Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)
III 期 COBRE:神经精神疾病 (MIND) 的多模态成像
- 批准号:
10372242 - 财政年份:2018
- 资助金额:
$ 26.69万 - 项目类别:
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in Children
弥漫性轻度脑损伤对儿童临床结果的影响
- 批准号:
9685257 - 财政年份:2016
- 资助金额:
$ 26.69万 - 项目类别:
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in Children
弥漫性轻度脑损伤对儿童临床结果的影响
- 批准号:
9185679 - 财政年份:2016
- 资助金额:
$ 26.69万 - 项目类别:
A Multidimensional Investigation of Cognitive Control Deficits in Psychopathology
精神病理学中认知控制缺陷的多维调查
- 批准号:
8899274 - 财政年份:2014
- 资助金额:
$ 26.69万 - 项目类别:
A Multidimensional Investigation of Cognitive Control Deficits in Psychopathology
精神病理学中认知控制缺陷的多维调查
- 批准号:
8691200 - 财政年份:2014
- 资助金额:
$ 26.69万 - 项目类别:
Attentional Bias Modification: Efficacy and Mechanisms of Action in Cocaine Addic
注意偏差修正:可卡因成瘾者的功效和作用机制
- 批准号:
8190807 - 财政年份:2012
- 资助金额:
$ 26.69万 - 项目类别: