MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目的最初目的是评估时间和空间完整性（即，通过研究对相同的一对滴答声、相同的一对音调和不同的一对音调的电磁和血液动力学反应，在精神分裂症患者（SP）和健康对照者（HC）中检测感觉门控网络的连通性。此外，我们还提出了研究基础听觉注意的成像标记物，临床表现的认知测试和单核苷酸多态性之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the sensory gating network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic and hemodynamic response to an identical pair of clicks, an identical pair of tones and a non-identical pair of tones. In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.