MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本项目的最初目的是通过研究相同的短声对、相同的音调对和不同的音调对的电磁和血流动力学反应来评估精神分裂症患者(SP)和健康对照组(HC)感觉门控网络的时间和空间完整性(即连通性)。此外，我们还建议研究基础听觉注意的影像指标、认知测试的临床表现和单核苷酸多态之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the sensory gating network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic and hemodynamic response to an identical pair of clicks, an identical pair of tones and a non-identical pair of tones. In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.