EFFECTS OF FETAL BISPHENOL A EXPOSURE ON OOGENESIS IN PRIMATES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 双酚A（BPA）是一种广泛使用的化合物，存在于塑料和用于食品的罐头衬里中，当怀孕的母鼠暴露于低剂量时，已被证明对小鼠的后代有有害影响。该项目将测量未怀孕和怀孕猴子的BPA代谢，并确定对卵或卵巢的影响是否会在灵长类动物的发育后代中观察到，就像在小鼠中一样。由于所使用的剂量将与目前人体血液中的BPA水平相似，因此结果应与人类健康直接相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bisphenol A (BPA) is a widely used compound found in plastics and the lining of cans used for food that has been shown to have deleterious effects on offspring of mice when the pregnant dams are exposed to low doses. This project will measure BPA metabolism in non-pregnant and pregnant monkeys and determine if effects on eggs or ovaries are seen in developing offspring in primates as they are in mice. Because the dose used will be similar to current human blood levels of BPA, the results should have direct relevance to human health.