BISPHENOL A METABOLISM AND EFFECTS IN A PRIMATE MODEL

双酚 A 在灵长类动物模型中的代谢和影响

• 批准号: 8357337
• 负责人: CATHERINE A VANDEVOORT
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357337
• 关键词: Adult; Affect; California; Chemicals; Collection; Data; Drug or chemical Tissue Distribution; Excretory function; Exposure to; Female; Fetus; Foundations; Funding; Grant; Health Policy; Human; Macaca mulatta; Metabolism; Modeling; Mus; National Center for Research Resources; Oogenesis; Pathway interactions; Primates; Principal Investigator; Production; Research; Research Infrastructure; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; base; biological systems; bisphenol A; cost; exposed human population; fetal; pregnant; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bisphenol A (BPA) is one of the highest volume chemicals in production, and over 90% of people in the US are exposed to low levels on a daily basis. Recent studies in the mouse indicate that exposure to low levels of this estrogenic chemical adversely affects a wide range of biological systems. However, there is a lack of information about the relevance of mouse studies to human exposure, which has prevented the use of these studies to inform human health policy decisions. Data from a primate model will help to bridge the gap between mouse and human. This proposal supports supplemental activities to an already funded grant from NIH. The funded grant "Effects of Fetal Bisphenol A Exposure on Oogenesis in Primates" involves the treatment of adult, pregnant female rhesus monkeys with BPA and the assessment of effects on oogenesis in female fetuses. This project covers two additional activities: 1) a study of the fate of BPA once it is orally ingested to determine the tissue distribution and excretion pathways and, 2) funds to support the collection and distribution of primate tissues from an ongoing NIH funded study to other Passport Foundation-funded investigators.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 双酚A（BPA）是生产量最大的化学品之一，美国90%以上的人每天都暴露在低水平的双酚A中。最近对小鼠的研究表明，暴露于低水平的这种雌激素化学品会对广泛的生物系统产生不利影响。 然而，缺乏关于小鼠研究与人类接触的相关性的信息，这阻碍了利用这些研究为人类健康政策决策提供信息。 来自灵长类动物模型的数据将有助于弥合小鼠和人类之间的差距。 该提案支持对NIH已经资助的赠款的补充活动。 受资助的赠款“胎儿双酚A暴露对灵长类动物卵子发生的影响”涉及用双酚A治疗成年怀孕雌性恒河猴，并评估对雌性胎儿卵子发生的影响。 该项目包括两项额外的活动：1）研究BPA口服后的命运，以确定组织分布和排泄途径，2）资助从NIH资助的正在进行的研究中收集和分发灵长类动物组织给其他护照基金会资助的研究人员。