EFFECTS OF FETAL BISPHENOL A EXPOSURE ON OOGENESIS IN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 双酚A(BPA)是一种广泛使用的化合物，在塑料和食品罐头衬里中发现，当怀孕的母鼠暴露在低剂量下时，这种化合物对小鼠的后代有有害影响。该项目将测量未怀孕和怀孕的猴子的双酚A新陈代谢，并确定在灵长类动物的后代发育中是否会像在老鼠身上一样对卵子或卵巢产生影响。由于使用的剂量将与目前人类血液中BPA的水平相似，因此结果应该与人类健康直接相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bisphenol A (BPA) is a widely used compound found in plastics and the lining of cans used for food that has been shown to have deleterious effects on offspring of mice when the pregnant dams are exposed to low doses. This project will measure BPA metabolism in non-pregnant and pregnant monkeys and determine if effects on eggs or ovaries are seen in developing offspring in primates as they are in mice. Because the dose used will be similar to current human blood levels of BPA, the results should have direct relevance to human health.