EFFECTS OF FETAL BISPHENOL A EXPOSURE ON OOGENESIS IN PRIMATES

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 双酚 A (BPA) 是一种广泛使用的化合物，存在于塑料和食品罐内衬中，已被证明当怀孕的母鼠接触低剂量时，会对小鼠后代产生有害影响。该项目将测量未怀孕和怀孕猴子的 BPA 代谢，并确定灵长类动物发育中的后代是否会像小鼠一样对卵子或卵巢产生影响。由于所使用的剂量与当前人体血液中的 BPA 水平相似，因此结果应与人类健康直接相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bisphenol A (BPA) is a widely used compound found in plastics and the lining of cans used for food that has been shown to have deleterious effects on offspring of mice when the pregnant dams are exposed to low doses. This project will measure BPA metabolism in non-pregnant and pregnant monkeys and determine if effects on eggs or ovaries are seen in developing offspring in primates as they are in mice. Because the dose used will be similar to current human blood levels of BPA, the results should have direct relevance to human health.