EFFECTS OF FETAL BISPHENOL A EXPOSURE ON OOGENESIS IN PRIMATES

胎儿双酚 A 暴露对灵长类动物卵子发生的影响

• 批准号: 8357290
• 负责人: CATHERINE A VANDEVOORT
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357290
• 关键词: Blood; California; Dose; Food; Funding; Grant; Health; Human; Measures; Metabolism; Monkeys; Mus; National Center for Research Resources; Oogenesis; Ovary; Plastics; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; bisphenol A; cost; egg; fetal; offspring; pregnant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bisphenol A (BPA) is a widely used compound found in plastics and the lining of cans used for food that has been shown to have deleterious effects on offspring of mice when the pregnant dams are exposed to low doses. This project will measure BPA metabolism in non-pregnant and pregnant monkeys and determine if effects on eggs or ovaries are seen in developing offspring in primates as they are in mice. Because the dose used will be similar to current human blood levels of BPA, the results should have direct relevance to human health.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 双酚A(BPA)是一种广泛使用的化合物，在塑料和食品罐头衬里中发现，当怀孕的母鼠暴露在低剂量下时，这种化合物对小鼠的后代有有害影响。该项目将测量未怀孕和怀孕的猴子的双酚A新陈代谢，并确定在灵长类动物的后代发育中是否会像在老鼠身上一样对卵子或卵巢产生影响。由于使用的剂量将与目前人类血液中BPA的水平相似，因此结果应该与人类健康直接相关。