NONHUMAN PRIMATE MODEL FOR TB VACCINES

结核病疫苗的非人类灵长类动物模型

• 批准号: 8172552
• 负责人: Paul Luciw
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172552
• 关键词: Animal Housing; Animals; Autopsy; California; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease Progression; Funding; Grant; Granuloma; Image; Institution; Lesion; Life; Macaca; Macaca mulatta; Methods; Modeling; Mycobacterium tuberculosis; Pathologic; Phase; Primates; Research; Research Personnel; Research Support; Resources; Roentgen Rays; Source; Training; Tuberculosis; United States National Institutes of Health; X-Ray Computed Tomography; biosafety level 3 facility; lung lobe; non-invasive monitor; nonhuman primate; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The animal biosafety level-3 (ABSL-3) facility at the California National Primate Research Center was completed and prepared for studies of Mycobacterium tuberculosis (M. tb.) in rhesus macaques. The ABSL-3 facility included both rooms for housing animals and a fully equipped necropsy suite for comprehensive pathologic analysis. Veterinary and research support staff were trained for studies of M. tb. in macaques in this facility. Macaques experimentally inoculated with M.tb. showed clinical signs of tuberculosis (TB). Novel stereology methods are being applied to quantitatively assess bacterial burden and lesions (granulomas) in lung lobes of these animals at necropsy. In addition, X-ray radiographs and computerized tomography (CT) images were obtained during the live-phase for non-invasive monitoring of tuberculosis disease progression.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 加州国家灵长类动物研究中心的动物生物安全3级（ABSL-3）设施已经完成，并准备用于结核分枝杆菌（M.结核病）在恒河猴中。 ABSL-3设施包括用于饲养动物的房间和用于全面病理分析的设备齐全的尸检室。 对兽医和研究支持人员进行了M. TB.在这个设施里的猕猴身上 实验性接种结核分枝杆菌的猕猴显示出结核病（TB）的临床症状。 采用新的体视学方法定量评估尸检时这些动物肺叶中的细菌负荷和病变（肉芽肿）。 此外，在活体阶段获得了X射线照片和计算机断层扫描（CT）图像，用于无创监测结核病进展。