Animal Resources and Laboratory Services

大多数NIAID A、B和C类病原体，以及几乎所有新出现的传染病 威胁人类的，是人畜共患病的病原体。因此，动物充当来源、蓄水池、携带者和 各种病原体的传播媒介。重要的是，与生物防御相关的制剂的研究和 新出现的传染病必须使用动物模型进行假说驱动的发病机制研究 以及测试和验证疫苗、治疗和诊断概念。DC Davis 主办高度互动的医学院和兽医学院。对于PSW-RCE，动物 资源和实验室服务核心提供广泛的动物建模专业知识、技术 向参与应对国家研究的科学界提供支持和工具 在生物防御病原体和新出现的传染病方面的倡议。一个重要的重点是 合作检测传染病的多重微球免疫分析技术的发展 与其他PSW-RCE项目合作。这个动物核心和 免疫分析开发服务核心旨在生产可交付的多路诊断系统 虫媒病毒血清监测。此外，动物核心协调RCE调查人员访问 DC Davis现有的与动物相关的广泛资源，包括比较中心 医学，老鼠生物学计划，加州国家灵长类研究中心， 媒介传播疾病，以及其他。核心为RCE调查人员提供访问专业知识的途径 通过创新的远程病理系统进行比较和实验病理学，具有链接功能 其他RCE站点：http://pswrce.compmed.ucdavis.edu/核心的使命是激励和促进 RCE研究人员和需要动物专业知识的科学家之间的协作研究互动 研究。这些互动旨在将RCE支持利用到独立研究计划中，以促进 NIH在生物防御和新发传染病研究方面的研究任务。申请续期补助金 作为核心应用，核心有三个主要目标：(1)发展核心基础设施(专业知识、接入、 优先次序、网站、充值、生物安全培训、应急网络)；(2)发展 多重免疫分析能力(通过与免疫分析合作对虫媒病毒进行血清监测 开发服务核心，以及(3)支持动物模型中新的合作研究机会 (如西尼罗河病毒、基孔肯加病毒、图拉氏弗朗西斯氏菌)需要动物资源和实验室

The majority of NIAID Category A, B, and C pathogens, and nearly all emerging infectious diseases that threaten humans, are zoonotic agents. Thus, animals serve as sources, reservoirs, carriers, and vectors of a wide variety of pathogens. Importantly, research on agents of relevance to biodefense and emerging infectious diseases must use animal models for hypothesis-driven investigation of pathogenesis and immunity, as well as testing and validating vaccine, therapeutic, and diagnostic concepts. DC Davis hosts highly interactive Schools of Medicine and Veterinary Medicine. For the PSW-RCE, the Animal Resources and Laboratory Services Core offers a broad array of animal modeling expertise, technical support, and instrumentation to the scientific community that is involved in responding to national research initiatives in biodefense pathogens and emerging infectious diseases. An important emphasis is on the development of multiplex microbead immunoassays for infectious disease detection through collaborations with other PSW-RCE Projects. A highly interactive collaboration between this Animal Core and the Immunoassay Development Services Core aims to produce a deliverable multiplex diagnostic system for arbovirus serosurveillance. Additionally, the Animal Core coordinates access of RCE investigators to a broad array of existing animal-related resources at DC Davis, including the Center for Comparative Medicine, the Mouse Biology Program, the California National Primate Research Center, the Center for Vector Borne Diseases, and others. The Core provides access for RCE investigators to expertise in comparative and experimental pathology through an innovative telepathology system, with capabilities to link other RCE sites: http://pswrce.compmed.ucdavis.edu/ The Core's mission is to stimulate and facilitate collaborative research interactions among RCE investigators and scientists needing expertise in animal research. These interactions aim to leverage RCE support into independent research programs that foster the NIH research mission in biodefense and emerging infectious disease research. For the renewal grant application, the Core has three major objectives: (1) development of Core infrastructure (expertise, access, prioritization, website, recharge, biosafety training, emergency response network), (2) development of multiplex immunoassay capabilities (serosurveillance of arboviruses via collaboration with the Immunoassay Development Services Core, and (3) support for new collaborative research opportunities in animal models (e.g., West Nile virus, Chikungunga virus, Francisella tularensis) needing animal resources and laboratory