Animal Resources and Laboratory Services

动物资源和实验室服务

• 批准号: 7675507
• 负责人: Paul Luciw
• 金额: $ 18.74万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7675507
• 关键词: Animal Experimentation; Animal Model; Animals; Antibodies; Applications Grants; Arbovirus Infections; Arboviruses; Biological Markers; Biology; California; Categories; Certification; Collaborations; Communicable Diseases; Communities; Computer Simulation; Consultations; Data Analyses; Databases; Detection; Development; Diagnostic; Effectiveness; Emergency Situation; Emerging Communicable Diseases; Experimental Pathology; Fostering; Francisella tularensis; Health Services; Histopathology; Human; Image; Immune response; Immunity; Immunoassay; Immunohistochemistry; In Situ Hybridization; Infectious Agent; Infectious Diseases Research; Investigation; Laboratories; Link; Medicine; Microspheres; Mission; Modeling; Mus; National Institute of Allergy and Infectious Disease; Pathogenesis; Pathology; Primates; Proteins; Protocols documentation; Reagent; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Route; Scientist; Services; Site; Slide; Source; Staining method; Stains; System; Technical Expertise; Telepathology; Testing; Tissue Array Analysis; Toxin; Training; Translational Research; United States National Institutes of Health; Validation; Vector-transmitted infectious disease; Veterinary Medicine; Viral; Virus; West Nile virus; animal resource; biodefense; chemokine; comparative; cytokine; design; good laboratory practice; human disease; innovation; instrumentation; laser capture microdissection; medical schools; nonhuman primate; pathogen; programs; respiratory; response; response marker; therapeutic vaccine; tissue processing; vector; web site

The majority of NIAID Category A, B, and C pathogens, and nearly all emerging infectious diseases that threaten humans, are zoonotic agents. Thus, animals serve as sources, reservoirs, carriers, and vectors of a wide variety of pathogens. Importantly, research on agents of relevance to biodefense and emerging infectious diseases must use animal models for hypothesis-driven investigation of pathogenesis and immunity, as well as testing and validating vaccine, therapeutic, and diagnostic concepts. DC Davis hosts highly interactive Schools of Medicine and Veterinary Medicine. For the PSW-RCE, the Animal Resources and Laboratory Services Core offers a broad array of animal modeling expertise, technical support, and instrumentation to the scientific community that is involved in responding to national research initiatives in biodefense pathogens and emerging infectious diseases. An important emphasis is on the development of multiplex microbead immunoassays for infectious disease detection through collaborations with other PSW-RCE Projects. A highly interactive collaboration between this Animal Core and the Immunoassay Development Services Core aims to produce a deliverable multiplex diagnostic system for arbovirus serosurveillance. Additionally, the Animal Core coordinates access of RCE investigators to a broad array of existing animal-related resources at DC Davis, including the Center for Comparative Medicine, the Mouse Biology Program, the California National Primate Research Center, the Center for Vector Borne Diseases, and others. The Core provides access for RCE investigators to expertise in comparative and experimental pathology through an innovative telepathology system, with capabilities to link other RCE sites: http://pswrce.compmed.ucdavis.edu/ The Core's mission is to stimulate and facilitate collaborative research interactions among RCE investigators and scientists needing expertise in animal research. These interactions aim to leverage RCE support into independent research programs that foster the NIH research mission in biodefense and emerging infectious disease research. For the renewal grant application, the Core has three major objectives: (1) development of Core infrastructure (expertise, access, prioritization, website, recharge, biosafety training, emergency response network), (2) development of multiplex immunoassay capabilities (serosurveillance of arboviruses via collaboration with the Immunoassay Development Services Core, and (3) support for new collaborative research opportunities in animal models (e.g., West Nile virus, Chikungunga virus, Francisella tularensis) needing animal resources and laboratory

大多数NIAID A、B和C类病原体以及几乎所有新发传染病 是人畜共患病的病原体。因此，动物作为来源，水库，载体， 各种病原体的载体。重要的是，研究与生物防御和 新出现的传染病必须使用动物模型进行假设驱动的发病机制研究 和免疫力，以及测试和验证疫苗，治疗和诊断概念。DC戴维斯 拥有高度互动的医学和兽医学院。对于PSW-RCE，动物 资源和实验室服务核心提供广泛的动物建模专业知识，技术 支持，并为参与响应国家研究的科学界提供仪器 在生物防御病原体和新出现的传染病方面的举措。一个重要的重点是 通过合作开发用于传染病检测的多重微珠免疫测定 其他PSW-RCE项目。这个动物核心和 免疫分析开发服务核心旨在生产可交付的多重诊断系统， 虫媒病毒血清监测此外，动物中心协调RCE调查人员访问 DC戴维斯现有的广泛的动物相关资源，包括比较研究中心 医学，小鼠生物学项目，加州国家灵长类动物研究中心， 病媒传播疾病及其他。核心为RCE调查人员提供以下专业知识： 通过创新的远程病理学系统进行比较和实验病理学， 其他RCE网站：http://pswrce.compmed.ucdavis.edu/核心的使命是激励和促进 RCE研究人员和需要动物领域专业知识的科学家之间的合作研究互动 research.这些互动旨在利用RCE支持独立的研究计划， 美国国立卫生研究院在生物防御和新兴传染病研究方面的研究使命。为了续约补助金 核心有三个主要目标：（1）核心基础设施的发展（专业知识，访问， 优先次序、网站、补充、生物安全培训、应急网络），（2）开发 多重免疫测定能力（通过与免疫测定合作进行虫媒病毒血清监测 开发服务核心，以及（3）支持动物模型中的新合作研究机会 (e.g.,西尼罗河病毒、基孔肯加病毒、土拉弗朗西斯菌）需要动物资源和实验室