PHARMACOKINETIC STUDY OF PROSTRATIN AND PRODRUG

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 药物诱导治疗包括有意激活潜伏病毒的复制，并结合抗病毒治疗。在接受HAART的艾滋病毒/艾滋病患者中，这种方法可以激活病毒的产生，然后HAART中的抗病毒抑制剂将靶向并抑制病毒的产生。前列环素是一种蛋白激酶激活剂，已在细胞培养系统和SCID-Hu小鼠模型中被测试为激活潜伏的艾滋病毒。前列腺素是一种佛波酯，它能激活蛋白激酶C，进而激活调节病毒转录的细胞信号通路。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pharmacologic induction therapy involves the intentional activation of the replication of latent virus combined with anti-viral therapy. This approach in HIV/AIDS patients receiving HAART could activate production of virus, which will then be targeted and inhibited by the anti-viral inhibitors in HAART. Prostratin is a protein kinase activator that has been tested for activation of latent HIV in cell culture systems and in the SCID-hu mouse model. The compound prostratin, a phorbol ester, activates protein kinase C, which subsequently activates cell signaling pathways that regulate viral transcription.