PHARMACOKINETIC STUDY OF PROSTRATIN AND PRODRUG

前列腺素及其前药的药代动力学研究

• 批准号: 7715650
• 负责人: Paul Luciw
• 金额: $ 8.45万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715650
• 关键词: AIDS/HIV problem; Cell Culture System; Computer Retrieval of Information on Scientific Projects Database; Drug Kinetics; Funding; Genetic Transcription; Grant; HIV; Highly Active Antiretroviral Therapy; Institution; Latent Virus; Neoadjuvant Therapy; Patients; Phorbol Esters; Prodrugs; Production; Protein Kinase; Protein Kinase C; Research; Research Personnel; Resources; SCID-hu Mice; Signal Pathway; Signal Transduction; Source; Testing; United States National Institutes of Health; Viral; Virus; Virus Inhibitors; mouse model; prostratin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pharmacologic induction therapy involves the intentional activation of the replication of latent virus combined with anti-viral therapy. This approach in HIV/AIDS patients receiving HAART could activate production of virus, which will then be targeted and inhibited by the anti-viral inhibitors in HAART. Prostratin is a protein kinase activator that has been tested for activation of latent HIV in cell culture systems and in the SCID-hu mouse model. The compound prostratin, a phorbol ester, activates protein kinase C, which subsequently activates cell signaling pathways that regulate viral transcription.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 药物诱导治疗包括有意激活潜伏病毒的复制并联合抗病毒治疗。 在接受HAART的HIV/AIDS患者中，这种方法可以激活病毒的产生，然后被HAART中的抗病毒抑制剂靶向和抑制。 Prostratin是一种蛋白激酶激活剂，已在细胞培养系统和SCID-hu小鼠模型中测试了其对潜伏HIV的激活作用。 化合物prostratin，一种佛波醇酯，激活蛋白激酶C，随后激活调节病毒转录的细胞信号通路。