International Research in Thailand

我们之前已经在泰国北部传播非结核分枝杆菌感染的患者中发现了干扰素伽马的自身抗体。我们还表明，献血者没有这些自身抗体。去年，我们通过了协议，并在泰国开发了基础设施来执行这个项目。此外，我们已在台湾和泰国的其他地点确定了这些病例的诊断地点。我们已经证实在来自不同部位的多个受试者中存在抗干扰素伽马自身抗体。我们还发现了一组患有自身抗体和胸腺瘤的人群，胸腺瘤是胸腺癌的一种形式。我们已经建立了当地的实验室支持，以获得适当的淋巴细胞计数和血浆样本以及细胞因子刺激，以便运往NIH进行分析。

We have previously identified autoantibodies to interferon gamma in patients in northern Thailand who have disseminated nontuberculous mycobacterial infections. We have also shown that blood bank donors do not have these autoantibodies. This last year we have passed the protocol and developed the infrastructure in Thailand to execute this project. In addition, we have identified sites in Taiwan and other sites in Thailand at which these cases are diagnosed. We have confirmed the presence of anti-interferon gamma autoantibodies in multiple subjects from the various sites. We have also identified a population with autoantibodies and thymoma, a form of thymic cancer. We have developed the local laboratory support to obtain appropriate lymphocyte counts and plasma samples and cytokine stimulations for shipment to the NIH for analysis.