International Research in Thailand

泰国的国际研究

• 批准号: 7732717
• 负责人: Steven Holland
• 金额: $ 5.52万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732717
• 关键词: Anonymous Testing; Asians; Autoantibodies; Blood Banks; Disease; Enrollment; Goals; Histoplasmosis; Interferon Type II; International; Laboratories; Lymphocyte Count; Mycobacterium Infections; Opportunistic Infections; Patients; Plasma; Population; Protocols documentation; Reporting; Research; Research Ethics Committees; Research Infrastructure; Sampling; Series; Thailand; United States; United States National Institutes of Health; cytokine

We have previously shown that autoantibodies to interferon gamma exist in patients in this population in northern Thailand, and that blood bank donors do not have these autoantibodies. We have spend the last year developing the protocol and infrastructure in Thailand to execute this project, which is now ready to enroll as soon as the final IRB approvals are received. We have developed the local laboratory support to obtain appropriate lymphocyte counts and plasma samples and cytokine stimulations for shipment to the NIH for analysis.

我们之前已经证明，泰国北方该人群的患者中存在干扰素γ的自身抗体，而血库捐献者不存在这些自身抗体。我们花了去年的时间在泰国制定了执行该项目的方案和基础设施，现在已经准备好在收到IRB的最终批准后立即招募。我们已经开发了当地实验室支持，以获得适当的淋巴细胞计数和血浆样本以及细胞因子刺激物，并将其运送至NIH进行分析。