Bone Marrow Stem Cells Participation in Solid Organ Cancers Carcinogenesis

骨髓干细胞参与实体器官癌的癌变

• 批准号: 7965933
• 负责人: Itzhak Avital
• 金额: $ 14.73万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7965933
• 关键词: Area; Bone Marrow; Bone Marrow Stem Cell; Cells; Clinical; Goals; Human; Malignant Neoplasms; Non-Malignant; Organ; Reporter Genes; SCID Mice; Site; Solid; Stem cells; Transplantation; Wound Healing; base; cancer therapy; carcinogenesis; clinically significant; mouse model; neoplastic cell; novel; receptor

In this project we will transplant Nude/SCID mice with human bone marrow. Subsequently, we will transplant HLA matched various human cancers to variou sites. We will determine whether bone marrow derrived stem cells caarrying one reporter gene are migrating preferentially to areas of active cancers as in "healing wound". Since both tumor cells and the stem cells will carry a different reporter gene, we will be able to determine whether fusion occured. If fusion occur to any clinical significance we will try to understand its mechanism, receptor and block it. We will also determine what makes normal bone marrow stem cells migrate into cancer and participate in carcinogenesis

在这个项目中，我们将用人类骨髓移植裸鼠/SCID小鼠。随后，委员会注意到， 我们将把HLA匹配的各种人类癌症移植到不同的部位。我们将确定 携带一个报告基因的骨髓干细胞是否迁移 优选在“愈合伤口”中的活性癌症区域。由于肿瘤细胞和 干细胞将携带不同的报告基因，我们将能够确定是否 发生了融合。如果融合发生任何临床意义，我们将尝试了解其 我们还将确定是什么使正常的骨髓干细胞 细胞迁移到癌细胞中并参与癌的发生