Isolation and Purification of Cancer Stem Cells Based on Functional Approaches

基于功能方法的癌症干细胞的分离和纯化

• 批准号: 8552929
• 负责人: Itzhak Avital
• 金额: $ 14.66万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552929
• 关键词: Cells; Cholangiocarcinoma; Goals; Malignant Neoplasms; Methodology; Organ; Pancreatic Adenocarcinoma; Primary carcinoma of the liver cells; Solid; Stomach; base; cancer stem cell; cancer therapy; malignant breast neoplasm; melanoma; novel; self renewing cell

In this project we investigate wide array of cancers: hepatocellular carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, breast cancer, melanoma, and gastric cancersThis project has two prongs:One, where we use a functional approach to identify the "best" cancer stem cell usiong all previously described methodes and markers and subjecting them to a rigorous tesing methodology. Once identified we will try to target these cells via the specific marker in attempt to generate novel cancer therapy.Two, using a novel methodology we try to isolate the self renwing cells via asymmetric division in various cancers and determine whether these are the "fitest" cancer stem cells

在这个项目中，我们研究了广泛的癌症：肝细胞癌，胆管癌，胰腺癌，乳腺癌，黑色素瘤和胃癌。这个项目有两个方面：一，我们使用功能性方法来识别“最好的”癌症干细胞，使用所有先前描述的方法和标记物，并对它们进行严格的测试方法。一旦确定，我们将尝试通过特定标志物靶向这些细胞，试图产生新型癌症疗法。第二，使用一种新的方法，我们尝试通过不对称分裂分离各种癌症中的自我修复细胞，并确定这些细胞是否是“最合适的”癌症干细胞

项目成果

Regional chemotherapy for pancreatic cancer.

胰腺癌的区域化疗。

• DOI: 10.1002/jso.21975
• 发表时间: 2011
• 期刊: Journal of surgical oncology
• 影响因子: 2.5
• 作者: Avital,Itzhak

Laparoscopic appendectomy for Amyand's hernia: a modern approach to a historic diagnosis.

腹腔镜阑尾切除术治疗阿米扬德疝气：历史性诊断的现代方法。

• DOI: 10.1007/s11605-010-1386-5
• 发表时间: 2011
• 期刊: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
• 作者: Mullinax,JohnE;Allins,Alexander;Avital,Itzhak
• 通讯作者: Avital,Itzhak