Isolation and Purification of Cancer Stem Cells Based on Functional Appraoch

基于功能方法的癌症干细胞的分离和纯化

• 批准号: 8157574
• 负责人: Itzhak Avital
• 金额: $ 26.02万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157574
• 关键词: base; cancer stem cell

In this project we investigate wide array of cancers: hepatocellular carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, breast cancer, melanoma, and gastric cancers This project has two prongs: One, where we use a functional approach to identify the "best" cancer stem cell usiong all previously described methodes and markers and subjecting them to a rigorous tesing methodology. Once identified we will try to target these cells via the specific marker in attempt to generate novel cancer therapy. Two, using a novel methodology we try to isolate the self renwing cells via asymmetric division in various cancers and determine whether these are the "fitest" cancer stem cells

在这个项目中，我们研究了广泛的癌症：肝细胞癌，胆管癌，胰腺癌，乳腺癌，黑色素瘤和胃癌。这个项目有两个方面：一，我们使用功能性方法来识别“最好的”癌症干细胞，使用所有先前描述的方法和标记物，并对它们进行严格的测试方法。一旦确定，我们将尝试通过特定的标志物靶向这些细胞，试图产生新的癌症治疗。第二，我们使用一种新的方法，试图通过不对称分裂分离各种癌症中的自我修复细胞，并确定这些细胞是否是“最合适的”癌症干细胞。