Asymmetric Division and Self Renewal of Cancer Stem Cells

癌症干细胞的不对称分裂和自我更新

• 批准号: 8157572
• 负责人: Itzhak Avital
• 金额: $ 26.02万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157572
• 关键词: cancer stem cell; self-renewal

We used a novel methode to identify asymmetric division in keeping with the immortal strand hyp[othesis. We subsequently, identified a novel factor: the self-renewal factor that induces asymmetric division in cancer stem cells. We plan to purify this protein and generate novwl anticancer therapy by blocking its receptor or the facore itself inorder to stop self renewal. In addition by identifying the asymmetrically dividing cells in cancer (for the first time) we subsequently identified markers which are associated specifically with cancer stem cells.

我们使用了一种新的方法来识别与不朽链Hyp[卵合]一致的不对称分裂。随后，我们确定了一个新的因子：诱导肿瘤干细胞不对称分裂的自我更新因子。我们计划纯化这种蛋白，并通过阻断其受体或因子本身来产生新的抗癌疗法，以阻止自我更新。此外，通过鉴定癌症中不对称分裂的细胞(首次)，我们随后确定了与癌症干细胞特定相关的标记。