Immune balance-regulating interleukins as targets for immunotherapy

免疫平衡调节白细胞介素作为免疫治疗的靶标

• 批准号: nhmrc : 1085509
• 负责人: A/Pr Di Yu
• 金额: $ 31.57万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-balance-regulating-targets-immunotherapy/519091
• 关键词: Immune; balance; regulating; interleukins; targets

The immune balance is crucial to human health. Interleukins are a group of proteins secreted by immune cells to mediate their communication. They tune up or down immune responses, thus as attractive targets for immunotherapy to restore the immune balance to treat autoimmune diseases, allergies and infections. This fellowship will support translational research to develop Interleukin-2 (IL-2) and IL-21-based novel immunotherapies for autoimmune disease, infection and allergy.

免疫平衡对人体健康至关重要。白细胞介素是免疫细胞分泌的一组蛋白质，用于调节免疫细胞间的通讯。它们调节或抑制免疫反应，因此成为免疫疗法恢复免疫平衡以治疗自身免疫性疾病、过敏和感染的有吸引力的靶点。该奖学金将支持转化研究，开发基于白细胞介素-2 （IL-2）和il -21的新型免疫疗法，用于自身免疫性疾病、感染和过敏。