Leptin as a natural regulator of TFH cell differentiation and vaccination response

瘦素作为 TFH 细胞分化和疫苗接种反应的天然调节剂

• 批准号: nhmrc : GNT1147769
• 负责人: A/Pr Di Yu
• 金额: $ 58.67万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/leptin-natural-regulator-vaccination-response/1348848
• 关键词: Leptin; natural; regulator; TFH; cell

Follicular helper T (Tfh) cells constitute a CD4+ T cell subset that plays an instrumental role to support protective antibody responses in infection and vaccination. Although malnutrition is associated with poor vaccine responses and increased risks of infections, the mechanism is poorly understood. We will investigate the mechanism by which leptin, a hormone secreted by adipose cells, regulates Tfh cell function and vaccination response.

滤泡辅助性T（Tfh）细胞构成CD4+ T细胞亚群，其在支持感染和疫苗接种中的保护性抗体应答中起工具性作用。虽然营养不良与疫苗反应不良和感染风险增加有关，但其机制尚不清楚。我们将研究瘦素，脂肪细胞分泌的激素，调节Tfh细胞功能和疫苗接种反应的机制。