Follicular cytotoxic T cell differentiation and function in infection and B-cell lymphoma

滤泡细胞毒性 T 细胞在感染和 B 细胞淋巴瘤中的分化和功能

• 批准号: nhmrc : GNT1147709
• 负责人: A/Pr Di Yu
• 金额: $ 95.06万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/follicular-cytotoxic-t-cell-lymphoma/1348845
• 关键词: Follicular; cytotoxic; cell; differentiation; function

Cytotoxic T cells eliminate infected or cancerous cells, constituting a major arm of the immune defence. In this study, we will investigate a subset of cytotoxic T cells that particularly migrate into B cell follicles to control infection and malignancy. Understanding of the differentiation and function of this subset, termed as follicular cytotoxic T (TFC) cells, will help us to develop new strategies to treat EBV and HIV infections as well as B cell lymphomas.

细胞毒性T细胞消除感染或癌细胞，构成免疫防御的主要武器。在这项研究中，我们将研究一个细胞毒性T细胞亚群，特别是迁移到B细胞滤泡，以控制感染和恶性肿瘤。了解这一亚群的分化和功能，称为滤泡细胞毒性T（TFC）细胞，将有助于我们开发新的策略来治疗EBV和HIV感染以及B细胞淋巴瘤。