Regulation of immune and inflammatory responses by short chain fatty acids and GPR43

短链脂肪酸和 GPR43 调节免疫和炎症反应

• 批准号: nhmrc : 606952
• 负责人: A/Pr Di Yu
• 金额: $ 36.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-immune-inflammatory-acids-gpr43/82051
• 关键词: Regulation; immune; inflammatory; responses; short

Innate immune mechanisms provide essential signals that determine the outcome of immune responses. The identity of these innate mechanisms may provide opportunities for manipulating immune responses, or controlling inflammatory responses. This proposal centers around a new and little-studied receptor, GPR43, which binds products of bacterial metabolism. This molecular pathway may explain how diet affect immune responses.

先天免疫机制提供了决定免疫反应结果的基本信号。这些先天机制的同一性可能为操纵免疫反应或控制炎症反应提供机会。这一建议围绕着一种新的和很少研究的受体GPR43，它结合细菌代谢产物。这种分子途径可以解释饮食如何影响免疫反应。