Specialised subsets of T follicular helper cells in the control of infection and immune pathology

滤泡辅助 T 细胞的特殊亚群在控制感染和免疫病理学中的作用

• 批准号: nhmrc : 1002162
• 负责人: A/Pr Di Yu
• 金额: $ 39.6万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/specialised-subsets-t-immune-pathology/108781
• 关键词: Specialised; subsets; follicular; helper; cells

Defective or uncontrolled production of antibodies leads to increased susceptibility to infection, allergies, and autoimmune diseases. A type of T cell called follicular helper (Tfh) has emerged as a key controller of both protective and pathologic antibody production. We have data suggesting there are specialised Tfh subsets, each controlling different stages and outcomes of antibody responses. Identifying how each subset is regulated and functions will provide novel targets to treat these chronic debilitating diseases.

抗体的产生有缺陷或不受控制会导致感染、过敏和自身免疫性疾病的易感性增加。一种称为滤泡辅助细胞 (Tfh) 的 T 细胞已成为保护性和病理性抗体产生的关键控制器。我们有数据表明存在专门的 Tfh 子集，每个子​​集控制抗体反应的不同阶段和结果。确定每个子集的调节方式和功能将为治疗这些慢性衰弱性疾病提供新的靶点。