Follicular helper T cell development and function: from mechanisms to application

抗体是大多数成功接种疫苗的基础。抗体反应减弱会导致免疫缺陷，而抗体反应过多则会导致自身免疫性疾病。我们正在研究一种新发现的特殊辅助性T细胞亚群，称为滤泡辅助性T细胞，它对调节高亲和力和长寿抗体反应至关重要。这些知识应该为设计更好的疫苗、控制感染或治疗自身免疫性疾病提供新的策略。

Antibodies are the basis of most successful vaccinations. Diminished antibody responses lead to immunodeficiency while excessive antibody responses contribute to autoimmune diseases. We are studying a newly identified specialised helper T cell subset, termed follicular helper T cells, which is essential to regulate the high-affinity and long-lived antibody responses. The knowledge should provide new strategies to design better vaccines, to control infections, or to treat autoimmune disorders.