Human developmental toxicity of metal mixture exposure from e-waste recycling

电子废物回收中接触金属混合物对人体发育的毒性

• 批准号: 8046947
• 负责人: Aimin Chen
• 金额: $ 172.29万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-27 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046947
• 关键词: Acids; Address; Adverse effects; Affect; Age-Months; Air; Aluminum; Area; Biological; Birth Weight; Birth length; Blood; Burn injury; Cadmium; Child; China; Chinese People; Chromium; Collaborations; Complex; Copper; Data; Developed Countries; Developing Countries; Development; Dust; Educational workshop; Electronics; Enrollment; Environmental Health; Exposure to; Fetal Growth; Fetus; Funding; Future; Ghana; Goals; Gold; Hair; Head circumference; Health; Health Policy; Heating; Heavy Metals; Human; India; Infant; Infant Development; Intervention; Investigation; Iron; Knowledge; Lead; Length; Manganese; Medical; Mercury; Metals; Mission; Morbidity - disease rate; Nickel; Nigeria; Outcome; Pakistan; Participant; Pathway interactions; Policy Making; Positioning Attribute; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Prevention strategy; Process; Production; Public Health; Recruitment Activity; Recycling; Research; Research Personnel; Site; Small for Gestational Age Infant; Soil; Solid; Solutions; Stream; Thyroid Function Tests; Thyroid Hormones; Tin; Toxic Environmental Substances; Toxic effect; Toxicant exposure; Umbilical Cord Blood; United States National Institutes of Health; Universities; Urine; Vietnam; Vulnerable Populations; Zinc; base; chromium hexavalent ion; design; fetal; follow-up; forging; global environment; global health; human data; human study; innovation; medical schools; metal poisoning; mortality; neurobehavioral; neurodevelopment; novel; perinatal health; pollutant; prospective; reproductive; response; stillbirth; toxicant; wasting

DESCRIPTION (provided by applicant): This application addresses one of the five thematic areas in the RFA-OD-10-005: Focusing on Global Health. Electronic waste (e-waste) has become a global environmental health problem because of its huge amount of production worldwide--approximately 20-50 million tons per year. E-waste contains high levels of several metals (lead [Pb], mercury [Hg], cadmium [Cd], chromium [Cr], manganese [Mn], etc.), but inappropriate and unregulated recycling exposes the workers and residents in many towns and villages in developing countries. Public health investigations into the exposure levels and potential toxicity in vulnerable population are urgently needed to address this critical environmental health problem. This research is closely related to NIH mission on global health to reduce preventable morbidity and mortality in developing countries. Developing fetuses and young children are especially susceptible to environmental toxicants. The metal mixture in e-waste is unique in its composition and concentrations, but the toxicity of this complex exposure is virtually unknown in developing fetuses and young children. The long-term goal is to investigate developmental effects of e-waste toxicant mixtures and provide human study evidence to inform future regulatory actions and public health prevention. The application will address this global health problem by recruiting 600 pregnant women (300 from an e-waste recycling site and 300 from a control site in China) and following up to 9 months postpartum. The applicants will accomplish three Specific Aims: 1) Characterize the e-waste metal mixture exposure in pregnant women and their fetuses; 2) Examine adverse pregnancy outcomes associated with e-waste metal mixture exposure; and 3) Investigate neurodevelopmental toxicity and thyroid hormone disruption of e-waste metal mixture exposure. The applicants will assess the environmental (air, dust, soil) and biological (maternal blood, urine, hair, cord blood) exposure markers of e-waste metal mixtures (Pb, Hg, Cd, Cr, Mn). Pregnancy outcomes (stillbirth, gestational length, preterm birth, birth weight, small for gestational age [SGA], birth length, head circumference, anogenital distance [AGD]), thyroid hormones (TSH, T4, T3), and infant neurodevelopment (Bayley Scales of Infant Development-2 [BSID-2]) will be examined. This study will provide novel data about metal toxicants in e-waste and developmental outcomes in humans, increase scientific knowledge about rarely studied mixture exposure, and inform environmental health policy making to reduce e- waste toxicant exposure in developing countries. PUBLIC HEALTH RELEVANCE: The proposed study will address a critical issue of global environmental health--enormous e-waste production but with prevailing primitive recycling in developing countries. This study will address the developmental effects of metal mixtures from primitive e-waste recycling activities. It will inform environmental health policy making to manage the e-waste and protect human health.

描述（由申请人提供）：本申请涉及RFA-OD-10-005中的五个主题领域之一：关注全球健康。电子废物已成为一个全球性的环境健康问题，因为它在全世界的产量巨大-每年约2 000万至5 000万吨。电子废物含有大量的几种金属（铅[Pb]、汞[Hg]、镉[Cd]、铬[Cr]、锰[Mn]等），但不适当和不受管制的回收使发展中国家许多城镇和村庄的工人和居民面临风险。为了解决这一严重的环境健康问题，迫切需要对脆弱人群的接触水平和潜在毒性进行公共卫生调查。这项研究与国家卫生研究院的全球卫生使命密切相关，即减少发展中国家可预防的发病率和死亡率。发育中的胎儿和幼儿特别容易受到环境毒物的影响。电子垃圾中的金属混合物在成分和浓度上是独特的，但这种复杂暴露的毒性在发育中的胎儿和幼儿中几乎是未知的。长期目标是调查电子废物有毒混合物对发育的影响，并提供人类研究证据，为未来的监管行动和公共卫生预防提供信息。该应用程序将通过招募600名孕妇（300名来自电子废物回收站，300名来自中国的对照站）和产后9个月的随访来解决这一全球健康问题。申请人将实现三个具体目标：1）描述孕妇及其胎儿接触电子废物金属混合物的特征; 2）检查与电子废物金属混合物接触相关的不良妊娠结果;和3）调查神经发育毒性和甲状腺激素干扰电子废物金属混合物暴露。申请人将评估电子废物金属混合物（铅、汞、镉、铬、锰）的环境（空气、灰尘、土壤）和生物（母体血液、尿液、头发、脐带血）暴露标志物。将检查妊娠结局（死产、胎龄、早产、出生体重、小于胎龄儿[SGA]、出生身长、头围、肛门与生殖器距离[AGD]）、甲状腺激素（TSH、T4、T3）和婴儿神经发育（Bayley婴儿发育量表-2 [BSID-2]）。这项研究将提供有关电子废物中金属毒物和人类发育结果的新数据，增加有关很少研究的混合物暴露的科学知识，并为环境卫生政策制定提供信息，以减少发展中国家的电子废物毒物暴露。 公共卫生相关性：拟议的研究将解决全球环境健康的一个关键问题-大量电子废物的产生，但发展中国家普遍进行原始回收。本研究将讨论原始电子废物回收活动中金属混合物对发展的影响。它将为环境卫生政策制定提供信息，以管理电子废物并保护人类健康。