COMMON LIFE STRESSES & FERTILITY IN PRIMATES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目研究日常生活压力在导致女性和非人类灵长类动物不孕症中的作用。它建立在我们以前的发现基础上，即有些人对压力非常敏感，容易表现出压力引起的生殖功能抑制，而另一些人则具有压力弹性，在压力下保持正常的月经周期。 我们已经发现，与更具压力弹性的个体相比，压力敏感的个体显示出较低的中枢多巴胺能神经元活性，这在生理学上和基因表达的变化中都有所表现。在这项补助金中，具体目标1是确定使用选择性5-羟色胺再摄取抑制剂（SSRI）治疗是否会增加压力敏感个体的压力恢复力。 具体目标2是确定在基因表达和活性的中枢神经系统的压力敏感和压力弹性的个人。具体目标3研究了压力对压力敏感和压力弹性个体卵泡和卵母细胞成熟的影响。 具体目标4检查了应激敏感动物与应激恢复动物的下丘脑-垂体-肾上腺（HPA）轴的活性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress-resilience of stress sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines the effects of stress on follicular and oocyte maturation in stress-sensitive and stress-resilient individuals. Specific Aim 4 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitivie vs. stress-resilient animals.