GENETIC LINKS TO ALCOHOLISM IN A NONHUMAN PRIMATE SPECIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是：（1）测试在临床研究中与酒精消耗增加相关的行为和生理标志物是否可以在猴子群体中测量，（2）是否有证据表明猴子的这些行为/生理标志物是可遗传的，以及（3）利用我们先前收集的每只猴子的基因型数据进行连锁分析，以鉴定携带与临床人群中的酒精中毒相关的表型的遗传信息的染色体区域。 评估的表型包括焦虑行为、酒精诱导的共济失调和脑脊液中的CSF 5-羟色胺水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are: (1) to test whether behavioral and physiological markers that have been linked to increased consumption of alcohol in clinical studies can be measured in a population of monkeys, (2) whether there is evidence in the monkey that these behaviors/physiological markers are heritable, and (3) to utilize our previously collected genotypic data in each monkey for linkage analysis to identify chromosomal regions carrying genetic information about phenotypes linked to alcoholism in clinical populations. Phenotypes being assessed include anxious behaviors, alcohol-induced ataxia and CSF serotonin levels in cerebrospinal fluid.