NOVEL STRATEGIES FOR OVARIAN CANCER PREVENTION

预防卵巢癌的新策略

• 批准号: 8173310
• 负责人: Jay W Wright
• 金额: $ 5.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173310
• 关键词: Affect; Age; Animals; Biological Factors; Cells; Computer Retrieval of Information on Scientific Projects Database; Detergents; Development; Disease; Epithelial; Epithelium; Etiology; Excision; Failure; Family history of; Funding; Gene Expression; Grant; Institution; Macaca mulatta; Malignant neoplasm of ovary; Methods; Modeling; Ovarian; Prevention strategy; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Surface; System; Testing; United States National Institutes of Health; Woman; anticancer research; cancer risk; nonhuman primate; novel strategies; ovarian cancer prevention; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in ovarian cancer research are limited by a failure to understand the etiology of the disease. In large part this is due to the absence of a natural model for epithelial ovarian cancerthe predominant form affecting womenand an inability for most animal systems to accurately reflect the normal biological factors that have been associated with ovarian cancer risk (namely age and ovarian function). As a result, the development of preventive strategies is limited by an inability to identify appropriate risk factors. We have utilized gene expression studies to identify changes in gene expression found in cultured ovarian cells from women with versus without a family history of the disease, and the rhesus model will be used to evaluate methods of altering gene expression in these "at risk" cells as a means to prevent ovarian cancer in women with a family history of the disease. In addition, we will use the nonhuman primate as a model to test whether the source of most ovarian cancers, the ovarian surface epithelium, may be eliminated using mild detergent to permanently reduce ovarian cancer risk. Current studies indicate that the surface epithelium does not regrow within 6 months of removal via deteregent.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 卵巢癌研究的进步受到无法理解该疾病病因的限制。 在很大程度上，这是由于缺乏上皮性卵巢癌的自然模型，主要影响女性的形式，而大多数动物系统无法准确反映与卵巢癌风险相关的正常生物学因素（即年龄和卵巢功能）。 结果，预防策略的发展受到无法识别适当风险因素的限制。 我们已经利用基因表达研究来确定来自患有该疾病家族史的女性与没有家族史的女性培养的卵巢细胞中发现的基因表达的变化，并且将使用恒星模型评估改变这些“处于危险”细胞中基因表达的方法，作为预防该疾病家族史的女性卵巢癌的一种手段。 此外，我们将使用非人类灵长类动物作为模型来测试大多数卵巢癌（卵巢表面上皮）是否可以使用轻度洗涤剂消除以永久降低卵巢癌风险。 当前的研究表明，表面上皮不会在通过变质的6个月内再生。