NOVEL STRATEGIES FOR OVARIAN CANCER PREVENTION
预防卵巢癌的新策略
基本信息
- 批准号:8357782
- 负责人:
- 金额:$ 4.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectCancer PatientCellsDataDetergentsDevelopmentDiagnosisDiseaseDown-RegulationEarly DiagnosisElementsEpitheliumFundingGenesGrantHistone AcetylationIndiumMalignant neoplasm of ovaryMessenger RNAMethylationMicroarray AnalysisMolecular AnalysisNational Center for Research ResourcesOvarianOvaryPrevention strategyPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRiskSourceStagingSurfaceSurvival RateSystemTherapeuticTranslatingUnited States National Institutes of HealthWomanbaseclinical applicationcostimprovednonhuman primatenovel strategiesoutcome forecastovarian cancer preventionprogramstreatment strategy
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The ovarian surface epithelium (OSE) is the source of most ovarian cancers in women, yet comprises less than 1/1,000th of the ovary. The basis for OSE transformation is poorly understood, hindering the development of improved strategies for treatment. Since the prognosis for ovarian cancer declines dramatically when the disease is diagnosed at later stages (95% cure rate at stage I, but a 5-year survival rate of only 10% at stage IV), strategies for prevention and early detection may offer the best hope of reducing the number of fatalities from ovarian cancer. We are developing two novel strategies for ovarian cancer prevention: first, we seek to eliminate the OSE completely, using detergent and mild abrasion (epitheliectomy); second, we wish to modulate FANCD2 expression in the OSE. This project more broadly seeks to establish a research program whereby microarray and molecular analysis of OSE cells from healthy, at risk, and cancer
patients will identify key elements in OSE transformation. The nonhuman primate system will be used to evaluate these elements as candidates for therapeutic manipulation, and the data will be translated into clinical application for ovarian cancer prevention and early
detection therapies. Current data indicate the OSE may be effectively removed without impairing ovarian function. In addition, we have eliminated FANCD2 gene methylation and histone acetylation as probable mechanisms for its downregulation in at-risk women. Ongoing research will determine whether miRNA's are affecting FANCD2 mRNA levels.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jay W Wright其他文献
Jay W Wright的其他文献
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{{ truncateString('Jay W Wright', 18)}}的其他基金
BIOLOGY OF THE PRIMATE OVARIAN SURFACE EPITHELIUM
灵长类动物卵巢表面上皮的生物学
- 批准号:
8357773 - 财政年份:2011
- 资助金额:
$ 4.36万 - 项目类别:
BIOLOGY OF THE PRIMATE OVARIAN SURFACE EPITHELIUM
灵长类动物卵巢表面上皮的生物学
- 批准号:
8173238 - 财政年份:2010
- 资助金额:
$ 4.36万 - 项目类别:
BIOLOGY OF THE PRIMATE OVARIAN SURFACE EPITHELIUM
灵长类动物卵巢表面上皮的生物学
- 批准号:
7958496 - 财政年份:2009
- 资助金额:
$ 4.36万 - 项目类别:
BIOLOGY OF THE PRIMATE OVARIAN SURFACE EPITHELIUM
灵长类动物卵巢表面上皮的生物学
- 批准号:
7715990 - 财政年份:2008
- 资助金额:
$ 4.36万 - 项目类别:
ESTROGEN-MEDIATED CELL CYCLE ARREST VIA P53 AND P21
通过 P53 和 P21 雌激素介导的细胞周期停滞
- 批准号:
7715991 - 财政年份:2008
- 资助金额:
$ 4.36万 - 项目类别:
Biology of the Primate Ovarian Surface Epithelium
灵长类动物卵巢表面上皮的生物学
- 批准号:
7357490 - 财政年份:2007
- 资助金额:
$ 4.36万 - 项目类别:
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