Oregon Clinical and Translational Research Institute

俄勒冈临床和转化研究所

• 批准号: 10693308
• 负责人: David H Ellison
• 金额: $ 967.3万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-02 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693308
• 关键词: Oregon; Clinical; Translational; Research; Institute

Overall - Project Summary The Oregon Clinical and Translational Research Institute (OCTRI) is a mature CTSA hub that has been accelerating research at Oregon Health & Science University (OHSU) since 2006. It has a stable, yet nimble, leadership structure that has functioned efficiently during the current funding cycle to meet its goals. OCTRI benefits from the guidance of several advisory groups in evaluation and planning and will use their input to continuously improve its structure. OCTRI’s many effective programs assist investigators and trainees by providing support services and fostering novel approaches to improve health in Oregon and beyond. OCTRI will now build on these strengths, while broadening its reach, to address goals that align with the national priorities articulated by NCATS and solidify its role within the CTSA network. OCTRI has developed nationally recognized programs to build the translational workforce, and will strengthen this base to bring more diversity, while also ensuring rigorous competencies are met. OCTRI has developed a regional reputation for leading innovation and have incorporated these assets in an optional function with the Knight Cancer Institute that supports the development of new therapeutics. OCTRI has built trust and capacity in research throughout rural Oregon and will now extend these efforts to the Portland metropolitan region. OCTRI’s current optional function has amplified the patient voice in research, and it will now be integrated into the community program in order to extend its reach. OCTRI has led in the development of national informatics platforms and will now leverage those to build internal support processes throughout OHSU to democratize these resources. At the same time, OCTRI has recognized limitations with regard to data sharing and will develop a novel optional function to incorporate Fast Healthcare Interoperability Resources to translate social determinants of health across electronic systems. OCTRI has been at the forefront of innovative outcome evaluation and will fully implement the Translational Science Benefits Model. These goals will be accomplished by engaging diverse stakeholders, by partnering with OHSU investigators, community coalitions, and business enterprises, and by fostering team science. Through these efforts, OCTRI will become even more essential for OHSU, for Oregon, and for the nation.

总体--项目摘要 俄勒冈州临床和翻译研究所(OCTRI)是一个成熟的CTSA中心，已经 自2006年以来，俄勒冈健康与科学大学(OHSU)加速了研究。它有一个稳定，但灵活， 在当前供资周期内有效运作以实现其目标的领导结构。OCTRI 受益于几个咨询小组在评估和规划方面的指导，并将利用他们的意见 不断优化结构。OCTRI的许多有效方案通过以下方式帮助调查人员和受训者 在俄勒冈州和其他地区提供支持服务和促进改善健康的新方法。OCTRI 现在将在这些优势的基础上，同时扩大其覆盖范围，以解决与国家 NCATS阐明的优先事项，并巩固了其在CTSA网络中的作用。OCTRI已在全国范围内发展 公认的计划，以建设翻译劳动力，并将加强这一基础，以带来更多的多样性， 同时确保满足严格的能力要求。OCTRI在该地区建立了领先的声誉 并已将这些资产纳入奈特癌症研究所的可选功能 支持新疗法的发展。OCTRI在整个农村地区建立了研究信任和能力 俄勒冈州，现在将把这些努力扩展到波特兰大都市区。OCTRI的当前可选功能 在研究中放大了患者的声音，现在将被整合到社区计划中，以便 扩大其影响范围。OCTRI在开发国家信息学平台方面发挥了主导作用，现在将利用 在整个OHSU建立内部支持程序，以使这些资源民主化。同时， OCTRI已认识到数据共享方面的局限性，并将开发一项新的可选功能，以 整合快速医疗互操作性资源，将健康的社会决定因素 电子系统。OCTRI一直站在创新成果评估的前列，并将全面实施 翻译科学惠益模式。这些目标将通过让不同的利益相关者参与来实现， 通过与OHSU调查人员、社区联盟和商业企业合作，并通过培养团队 科学。通过这些努力，OCTRI将变得对OHSU、俄勒冈州和 国家。

项目成果

Muscle Strength and Physical Performance Are Associated With Risk of Postfracture Mortality But Not Subsequent Fracture in Men.

• DOI: 10.1002/jbmr.4619
• 发表时间: 2022-08
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Alajlouni, Dima A.;Bliuc, Dana;Tran, Thach S.;Blank, Robert D.;Cawthon, Peggy M.;Ensrud, Kristine E.;Lane, Nancy E.;Orwoll, Eric S.;Cauley, Jane A.;Center, Jacqueline R.
• 通讯作者: Center, Jacqueline R.

Avapritinib in Patients With Advanced Gastrointestinal Stromal Tumors Following at Least Three Prior Lines of Therapy.

• DOI: 10.1002/onco.13674
• 发表时间: 2021-04
• 期刊: The oncologist
• 作者: George S;Jones RL;Bauer S;Kang YK;Schöffski P;Eskens F;Mir O;Cassier PA;Serrano C;Tap WD;Trent J;Rutkowski P;Patel S;Chawla SP;Meiri E;Gordon M;Zhou T;Roche M;Heinrich MC;von Mehren M
• 通讯作者: von Mehren M

'Never once was I thinking the c-word': Parent perspectives on the facilitators and barriers to getting a childhood cancer diagnosis.

• DOI: 10.1111/jocn.16511
• 发表时间: 2023-07
• 期刊: JOURNAL OF CLINICAL NURSING
• 影响因子: 4.2
• 作者: Christensen, Vivian;Parker, Kellee;Chan, Lai Hin Kimi;Saxton, Lauren;Cottrell, Erika
• 通讯作者: Cottrell, Erika

Short-Term High-Fat Feeding Does Not Alter Mitochondrial Lipid Respiratory Capacity but Triggers Mitophagy Response in Skeletal Muscle of Mice.

• DOI: 10.3389/fendo.2021.651211
• 发表时间: 2021
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Ehrlicher SE;Stierwalt HD;Newsom SA;Robinson MM
• 通讯作者: Robinson MM

Measuring glucose at the site of insulin delivery with a redox-mediated sensor.

• DOI: 10.1016/j.bios.2020.112221
• 发表时间: 2020-10-01
• 期刊: Biosensors & bioelectronics
• 影响因子: 12.6