Core-001

OCTRI信息学核心一直在加快OHSU的临床和翻译研究，我们的CTSA 联盟合作伙伴，以及更广泛的研究社区，通过创造创新的信息学方法， 基础设施和服务，自2006年以来，作为CTSA原始队列的成员。这些信息学方法 服务涵盖翻译领域，从翻译生物信息学到临床研究信息学， 和社区参与。在学术和应用信息学方面有坚实的基础，OCTRI Informatics Core为一系列不同的翻译工作人员提供培训。以此为基础 在之前的工作中，信息学核心将通过以下方式进一步催化临床和翻译研究 目标： 具体目标1：开发和实施新的、有针对性的信息学方法来解决翻译研究 解决瓶颈问题，并促成新的研究模式。 具体目标2：与其他CTSA以及其他基础广泛的努力协作，以提高利用率和 数据标准、互操作性以及数据共享和安全模型的扩展。 具体目标3：最好地为翻译研究人员提供信息学和数据科学方面的培训 实践，侧重于数据和方法的传播、数据的重复使用、严密性和可重复性。 我们战略的一个关键组成部分是通过合作的、 综合的多学科流程，包括科学家、信息专家、IT专家、临床医生、 道德和人类主体保护、社区成员和其他利益攸关方。我们将推动研究 通过开发和支持将临床护理和研究相结合的新信息学方法 企业，并促进招募患者参加临床试验，无论是在区域还是在整个CTSA 网络。我们将极大地丰富我们已经成熟的数据仓库，以纳入更广泛的数据类型 (例如，成像、组学、健康的社会决定因素)以及来自我们不断增长的合作伙伴网络的数据。我们会 充分利用OHSU对信息学治理、行业伙伴关系和人力资源的投资和承诺 主题保护专业知识，以开发创新的、保护隐私的数据共享方法 信息学概念和伦理原则。作为培训信息学专业人员和教育 国家的信息学劳动力，我们将为国家的临床带来新的和独特的教育机会 和翻译型劳动力。

The OCTRI Informatics Core has been accelerating clinical and translational research at OHSU, our CTSA Consortium partners, and the broader research community by creating innovative informatics methods, infrastructure, and services since 2006, as a member of the original CTSA cohort. These informatics methods and services cover the translational spectrum from translational bioinformatics, clinical research informatics, and community engagement. With a solid grounding in academic and applied informatics, the OCTRI Informatics Core has provided training to a diverse array of translational workforce members. Building on this prior work, the Informatics Core will further catalyze clinical and translational research through the following aims: Specific Aim 1: Develop and implement novel, targeted informatics approaches to solve translational research bottlenecks and enable new research modalities. Specific Aim 2: Collaborate with other CTSAs as well as other broad-based efforts to improve utilization and extension of data standards, interoperability, and data sharing and security models. Specific Aim 3: Provide training to the translational research workforce in informatics and data science best practices, focused on data and methods dissemination, data re-use, rigor, and reproducibility. A key component of our strategy is to target specific high-impact research bottlenecks through a collaborative, integrative, and multidisciplinary process including scientists, informaticians, IT experts, clinicians, experts in ethics and human subjects protection, community members, and other stakeholders. We will catalyze research by developing and supporting new informatics approaches that integrate the clinical care and research enterprises, and facilitate the recruitment of patients into clinical trials, both regionally and across the CTSA network. We will greatly enrich our already mature data warehouse to incorporate a broader array of data types (e.g., imaging, -omics, social determinants of health) as well as data from our growing partner network. We will leverage OHSU’s investment and commitment to informatics governance, industry partnerships, and human subjects protection expertise to develop innovative, privacy-preserving data sharing methods grounded in informatics concepts and ethical principles. As a leader in training informatics professionals and educating the nation’s workforce in informatics, we will bring new and unique educational opportunities to the nation’s clinical and translational workforce.