Core-005

OHSU在儿童健康，老年人口，整个生命周期的疾病， 服务不足的农村人口。然而，在对这些活动的协调支助方面存在着重大差距， 重要的计划，损害最佳性能和扩大这些努力。新的OCTRI 特殊人群综合股将加强儿童健康、老年人、疾病和 在整个生命周期中，以及服务不足的农村人口，对目前的需求进行了批判性分析， 满足这些需要的可行目标，最优先目标的执行，以及评估和 传播最有效的方法。计划的活动包括区域会议和务虚会 与调查人员和其他利益攸关方一道，开发工具包和其他教育模块， 信息学工具和其他为每个程序量身定制的技术。互联网服务供应商将与 CTSA网络采用CTSA其他站点开发的有效技术，并分享当地经过验证的 经过仔细评估的技术。这些努力将增进这些国家对健康相关问题的了解， 特别人群，从而改善干预措施，以优化他们的健康和福祉。 OCTRI临床和转化研究中心（CTRC）极大地扩展和增强了 在OHSU开展临床研究，在过去五年中取得了前所未有的增长。CTRC还 作为OHSU临床研究职业发展的主要场所。然而，CTRC上的压力源 业务和财务结构需要新的供资模式和更高的业务效率。 这些成就和挑战为OCTRI参与者的持续发展奠定了基础， 未来五年的临床相互作用（PCI）研究能力。CTRC将科学地催化 严谨，道德，可行和有效的以患者为导向的研究，重点是密集的 表型和早期临床试验的高优先领域的OHSU研究者。这些努力将 促进对许多人类疾病的了解，并为疾病特异性治疗奠定基础 来增进人类健康。CTRC还将继续利用和加强OCTRI教育 利用CTRC作为学生、研究者和研究人员的指导“实验室”， 进行以病人为导向的研究。最后，CTRC将完成向新的业务 模型作为大学共享资源（USR），纳入持续的质量改进，以确保 可持续和高效的运营和财务流程到位，以最佳方式支持PCI 在OHSU和该地区的研究。

OHSU has a robust research portfolio in child health, older populations, diseases across the lifespan, and underserved rural populations. However, there are significant gaps in coordinated support for these important programs that impair optimal performance and expansion of these efforts. The new OCTRI Integrating Special Populations unit (ISP) will enhance research in child health, older populations, diseases across the lifespan, and underserved rural populations with a critical analysis of current needs, development of feasible goals to address these needs, implementation of the highest priority goals, and evaluation and dissemination of the most effective processes. Planned activities include regional conferences and retreats with investigators and other stakeholders, development of toolkits and other educational modules, enhanced informatics tools, and other techniques tailored to each program. The ISP will coordinate closely with the CTSA network to adopt effective techniques developed at other CTSA sites, and to share local proven techniques after careful evaluation. These efforts will enhance knowledge of health-related issues in these special populations, leading to improved interventions to optimize their health and well-being. The OCTRI Clinical and Translational Research Center (CTRC) has greatly expanded and enhanced the conduct of clinical research at OHSU, with unprecedented growth over the past five years. The CTRC also serves as a major site for career development in clinical research at OHSU. However, stressors on CTRC operational and financial structures require a new funding model and increased operational efficiencies. These accomplishments and challenges set the stage for continued evolution of OCTRI’s Participant and Clinical Interactions (PCI) research capacity for the next five years. The CTRC will catalyze scientifically rigorous, ethical, feasible, and efficient patient-oriented research studies, with an emphasis on intensive phenotyping and early phase clinical trials in high priority areas for OHSU investigators. These efforts will advance knowledge of numerous human diseases and lay the foundations for disease-specific therapeutics to enhance human health. The CTRC will also continue to leverage and enhance the OCTRI Educational Program by utilizing the CTRC as the mentored “laboratory” for students, investigators, and study staff pursuing patient- oriented research. Finally, the CTRC will complete its transition to a new operational model as a University Shared Resource (USR), incorporating continuous quality improvement to ensure that sustainable and efficient operational and financial processes are in place to optimally support PCI research at OHSU and the region.