Training Program in Translational Cardiovascular Science

描述(由申请人提供)： 本申请要求在11-15年内继续支持威斯康星大学麦迪逊分校威斯康星大学心血管研究中心(CVRC)内的翻译心血管科学培训计划。CVRC位于医学与公共卫生学院(SMPH)，是一个校园范围的跨学科研究中心，拥有来自另外7所学校和学院以及27个学术部门的教职员工。所有这些机构都致力于开发基础研究、临床研究、诊断和治疗以及/或有关心血管疾病基础的公共教育项目。该培训计划为博士后医学博士和博士研究生(四个职位)以及博士后实习生(四个职位，要求增加一个职位)提供基础研究培训，目标是培养能够从分子到床边思考和工作的科学家。实际的近期目标是吸引和培训基础研究方面的临床医生，并吸引和培训具有临床动机的基础科学方面的研究生和博士后(博士)学生。此应用程序请求支持医生的研究性培训，作为其住院医师和研究员培训的一部分。该培训计划还资助翻译心血管科学的博士后和博士后(PHD)学员。本计划中的24名培训师是从CVRC成员中挑选出来的，他们的科学在重点领域(收缩/心力、离子通道/心律失常和血管生物学/动脉粥样硬化和细胞生物学/干细胞)的临床相关性，他们的培训记录，以及他们同行评议的研究计划的总体活动和影响。培训在威斯康星大学麦迪逊分校进行，并利用了这类培训的强有力的机构支持和环境，以及医学和公共卫生学院和整个大学的临床和基础科学系和教员之间建立的工作关系。培训者和受训者都参加核心活动，这些活动将该计划定义为一个具有凝聚力的实体。在这个心血管科学项目中接受培训的科学家和内科科学家处于独特的地位，可以应用基本的科学知识造福心血管疾病患者，心血管疾病是美国人死亡的首要原因。

DESCRIPTION (provided by applicant): This application requests continuing support for Years 11-15 for the Training Program in Translational Cardiovascular Science within the University of Wisconsin Cardiovascular Research Center (CVRC) at the University of Wisconsin-Madison. Housed in the School of Medicine and Public Health (SMPH), the CVRC is a campus-wide interdisciplinary research center with faculty members from seven additional schools and colleges and from 27 academic departments. All are dedicated to developing programs in basic research, clinical investigation, diagnosis and therapy, and/or public education concerning the basis for cardiovascular diseases. The training program provides basic research training for postdoctoral MD's and PhD's (four positions), as well as predoctoral trainees (four positions, with a request for one additional slot), with the goal of training scientists who will be capable of thinking and working "from molecule to bedside." The practical immediate aims are to attract and train clinicians in basic research, and to attract and train graduate and postdoctoral (PhD) students in clinically motivated basic science. This application requests support for research training of physicians as part of their resident and fellow training. The training program also funds predoctoral and postdoctoral (PhD) trainees in translational cardiovascular sciences. The 24 trainers in this program have been selected from members of the CVRC for the clinical relevance of their science in the focus areas (contractility/heart failure, ion channels/arrhythmias and vascular biology/atherosclerosis and cell biology/stem cells), their training records, and the overall activity and impact of their peer-reviewed research programs. Training takes place at UW-Madison and takes advantage of the strong institutional support and environment for such training, as well as the established working relationships between clinical and basic science departments and faculty both within the School of Medicine and Public Health and the University at large. Trainers and trainees all participate in core activities that define the program as a cohesive entity. The scientists and physician scientists trained in this translational cardiovascular science program are in unique positions to apply basic scientific knowledge to benefit patients with cardiovascular disease, the foremost cause of mortality among Americans.