Clinical and Translational Resaerch in the Pelvic Floor Disorders Network

描述(由申请人提供)：本申请建议通过在盆底疾病网络内的持续合作，促进女性盆底疾病的临床和翻译科学的发展。这项申请的总体目标是将Loyola调查人员的技能和才华贡献给正在进行的研究以及规划不同阶段的研究的设计、实施和传播。PFDN先前的研究突出了女性盆底疾病的显著流行。本申请描述了Loyola研究人员(包括过去和正在进行的贡献)、潜在参与者群体(包括临床卷编号)、设施(包括临床和翻译能力)以及拟议的临床研究的概念，以及伴随的翻译目标。该提案还将我们以前的捐款描述为下一个供资周期继续取得成功的证据。混合性尿失禁(MUI)是本领域的研究重点，在简要的概念上提出了研究建议。具体地说，这一概念为随机临床试验提出了广泛的框架设计，并对计划手术治疗压力性尿失禁的MUI女性进行了为期2年的随访。为这一概念规划了三个具体目标。临床目的是确定围手术期急迫性尿失禁治疗对围手术期尿失禁症状和尿失禁相关问题的疗效。第二个目标是翻译，并将继续PFDN在描述围手术期尿液微生物组方面的工作。此外，调查人员还将评估此类研究的招聘和留用问题。这项工作将科学地补充PFDN已建立的调查路线，该调查路线已开始作为ABC(抗胆碱能和肉毒杆菌比较)试验的补充研究。 相关性：美国女性受到盆底疾病的影响，包括尿失禁、盆腔器官脱垂和大便失禁，但临床和翻译科学不足以提供有效、持久的治疗。对这些常见疾病的病因和病理生理学的研究还很少。需要资源来寻求女性盆底疾病的临床和翻译方面的进展。

DESCRIPTION (provided by applicant): This application proposes work that advances the clinical and translational science of female pelvic floor disorders by continuing collaboration within the Pelvic Floor Disorders Network. The over-arching objective of this application is to contribute the skills and talents of Loyola investigators to on-going studies as well as the design, conduct and dissemination of studies in various stages of planning. Prior PFDN work has highlighted the striking prevalence of female pelvic floor disorders. This application describes the Loyola investigators (including past and on-going contributions), the potential participant population (including clinical volume numbers), facilities (including clinical and translational capabilities) and a concept for a proposed clinical study with concomitant translational aims. The proposal also describes our prior contributions as evidence of continuing success for the next funding cycle. Mixed urinary incontinence (MUI) is the area of research focus in the brief concept for the research proposal. Specifically, the concept proposes the broad skeleton design for a randomized clinical trial with 2-year follow-up to study women with MUI who plan surgery for treatment of stress urinary incontinence. Three specific aims are planned for the concept. The clinical aim is to determine the utility of peri-operative urge urinary incontinence therapy on peri-operative urinary incontinence symptoms and urinary incontinence-related bother over two years. The second aim is translational and will continue PFDN work on describing the peri-operative urinary microbiome. In addition, the investigators will assess recruitment and retention issues for such a study. This work will scientifically complement the PFDN's established line of investigation which has been started as a supplementary study to the ABC (Anticholinergic and Botulinum Comparison) trial. RELEVANCE: American women are affected by pelvic floor disorders, including urinary incontinence, pelvic organ prolapse and fecal incontinence, yet there is insufficient clinical and translational science to provide effective, durable treatment. The etiology and pathophysiology of these common conditions are grossly understudied. Resources are required to seek clinical and translational advances in female pelvic floor disorders.