Clinical and Translational Resaerch in the Pelvic Floor Disorders Network

盆底疾病网络的临床和转化研究

• 批准号: 8119178
• 负责人: LINDA BRUBAKER
• 金额: $ 1.49万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119178
• 关键词: Affect; Algorithms; American; Anti-Cholinergics; Area; Biology; Client satisfaction; Clinical; Clinical Research; Clinical Sciences; Collaborations; Complement; Consent; Counseling; Employee Strikes; Etiology; Fecal Incontinence; Female; Functional disorder; Funding; Investigation; Knowledge; Medicine; Natural History; Operative Surgical Procedures; Organ; Participant; Patients; Pelvic Floor Disorders; Pelvic Floor Muscle; Pelvis; Perioperative; Population; Postoperative Period; Prevalence; Ptosis; Questionnaires; Randomized; Randomized Clinical Trials; Research; Research Personnel; Research Proposals; Resources; Risk; Route; Severities; Skeleton; Staging; Stress Urinary Incontinence; Symptoms; Talents; Techniques; Testing; Time; Translational Research; Urge Incontinence; Urinary Incontinence; Urodynamics; Vagina; Visit; Woman; Work; base; botulinum; clinical care; cohort; design; evidence base; experience; follow-up; instrumentation; microbiome; skills; success; treatment as usual; urinary

DESCRIPTION (provided by applicant): This application proposes work that advances the clinical and translational science of female pelvic floor disorders by continuing collaboration within the Pelvic Floor Disorders Network. The over-arching objective of this application is to contribute the skills and talents of Loyola investigators to on-going studies as well as the design, conduct and dissemination of studies in various stages of planning. Prior PFDN work has highlighted the striking prevalence of female pelvic floor disorders. This application describes the Loyola investigators (including past and on-going contributions), the potential participant population (including clinical volume numbers), facilities (including clinical and translational capabilities) and a concept for a proposed clinical study with concomitant translational aims. The proposal also describes our prior contributions as evidence of continuing success for the next funding cycle. Mixed urinary incontinence (MUI) is the area of research focus in the brief concept for the research proposal. Specifically, the concept proposes the broad skeleton design for a randomized clinical trial with 2-year follow-up to study women with MUI who plan surgery for treatment of stress urinary incontinence. Three specific aims are planned for the concept. The clinical aim is to determine the utility of peri-operative urge urinary incontinence therapy on peri-operative urinary incontinence symptoms and urinary incontinence-related bother over two years. The second aim is translational and will continue PFDN work on describing the peri-operative urinary microbiome. In addition, the investigators will assess recruitment and retention issues for such a study. This work will scientifically complement the PFDN's established line of investigation which has been started as a supplementary study to the ABC (Anticholinergic and Botulinum Comparison) trial. RELEVANCE: American women are affected by pelvic floor disorders, including urinary incontinence, pelvic organ prolapse and fecal incontinence, yet there is insufficient clinical and translational science to provide effective, durable treatment. The etiology and pathophysiology of these common conditions are grossly understudied. Resources are required to seek clinical and translational advances in female pelvic floor disorders.

描述（由申请人提供）：本申请提出了通过在骨盆底疾病网络内继续合作推进女性骨盆底疾病临床和转化科学的工作。该应用程序的over-dedicated目标是贡献的技能和洛约拉调查员的才能进行中的研究，以及设计，在规划的各个阶段进行和研究的传播。先前的PFDN工作强调了女性盆底疾病的惊人患病率。本申请描述了洛约拉研究者（包括过去和正在进行的贡献），潜在的参与者人群（包括临床卷数量），设施（包括临床和翻译能力）和一个概念，为拟议的临床研究伴随翻译的目的。该提案还将我们以往的捐款描述为下一个供资周期继续取得成功的证据。混合性尿失禁（MUI）是该领域的研究热点，在简要的概念为研究建议。具体而言，该概念提出了广泛的骨架设计，用于随机临床试验，随访2年，以研究计划手术治疗压力性尿失禁的MUI女性。为这一概念规划了三个具体目标。临床目的是确定手术期急迫性尿失禁治疗对手术期尿失禁症状和尿失禁相关困扰的效用超过两年。第二个目标是翻译，并将继续PFDN在描述围手术期尿液微生物组方面的工作。此外，研究者将评估此类研究的招募和保留问题。这项工作将科学地补充PFDN的既定调查路线，该路线已开始作为ABC（抗胆碱能药物和肉毒杆菌素比较）试验的补充研究。 相关性：美国妇女受到骨盆底疾病的影响，包括尿失禁，盆腔器官脱垂和大便失禁，但没有足够的临床和转化科学提供有效，持久的治疗。这些常见疾病的病因学和病理生理学研究严重不足。需要资源来寻求女性盆底疾病的临床和转化进展。