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Chimpanzee Biomedical Research Resource

黑猩猩生物医学研究资源

基本信息

批准号：
8199811
负责人：
CHRISTIAN R ABEE
金额：
$ 256.57万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8199811
关键词：
Chimpanzee Biomedical Research Resource

项目摘要

DESCRIPTION (provided by applicant): This is a competing renewal application of a cooperative agreement supporting the "Chimpanzee Biomedical Research Resource" (CBRR) at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The University of Texas MD Anderson Cancer Center in Bastrop, TX. The CBRR is a national research resource of 159 chimpanzees housed within the chimpanzee housing complex of the KCCMR. The CBRR is one of only four research resources in the world capable of conducting biomedical research in this species. Over the past 35 years, the CBRR has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for maintaining chimpanzees and conducting research using this important model. The CBRR's primary objectives continue to focus on colony care and maintenance, provision of the infrastructure needed to conduct studies for investigators who need to access chimpanzees, and conducting studies to enhance the research value of chimpanzees. During the current funding period, we developed an informational website to help scientists assess the suitability of chimpanzees as relevant models for their studies and inform the public of the value of chimpanzees. We plan to continue to make available chimpanzee-derived cell lines, antibodies and other biological materials through the Chimpanzee Experimental Tools and Laboratory Reference Value Registry. The CBRR is organized into three functional cores that include the Resource Management Core, the Behavioral Management Core, and the Resource-related Research Core. Studies supported by the CBRR will continue to emphasize the characterization of the chimpanzee immune system and the numerous collaborative behavioral studies through the Behavioral Management Core. These include studies of the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures compared to untrained chimpanzees that must be anesthetized. The CBRR will continue to maintain its leadership role in the training of chimpanzees to voluntarily participate in research and clinical manipulations using positive reinforcement techniques. Beginning with this period of support, we plan to categorize all chimpanzees within the CBRR using the G-MARC as described in the RFA-RR-10-008. By expanding and improving the availability of CBRR resources, conducting resource-related research, and containing costs, the CBRR will continue to provide a critically important, highly specialized, research resource that addresses human health needs.

描述（由申请人提供）：这是一份支持“黑猩猩生物医学研究资源”(CBRR) 的合作协议的竞争续签申请，该协议位于德克萨斯州巴斯特罗普市德克萨斯大学 MD 安德森癌症中心的 Michale E. Keeling 比较医学和研究中心 (KCCMR)。 CBRR 是一个由 159 只黑猩猩组成的国家研究资源，这些黑猩猩居住在 KCCMR 的黑猩猩住宅区内。 CBRR 是世界上仅有的四个能够对该物种进行生物医学研究的研究资源之一。在过去的 35 年里，CBRR 开发了高度专业化的住房设施、实验室、管理技术和人员，这些对于维持黑猩猩和使用这一重要模型进行研究至关重要。 CBRR 的主要目标仍然是集中于群体护理和维护、为需要接触黑猩猩的研究人员提供开展研究所需的基础设施，以及开展研究以提高黑猩猩的研究价值。在当前资助期间，我们开发了一个信息网站，帮助科学家评估黑猩猩作为其研究相关模型的适用性，并向公众宣传黑猩猩的价值。我们计划继续通过黑猩猩实验工具和实验室参考值注册表提供黑猩猩衍生的细胞系、抗体和其他生物材料。 CBRR 分为三个功能核心，包括资源管理核心、行为管理核心和资源相关研究核心。 CBRR 支持的研究将继续强调黑猩猩免疫系统的特征以及通过行为管理核心进行的大量协作行为研究。其中包括对经过训练的黑猩猩进行研究操作的生理学和免疫学后果的研究，这些黑猩猩经过训练可以自愿配合研究程序，与未经训练的必须麻醉的黑猩猩相比。 CBRR 将继续保持其在训练黑猩猩自愿参与使用正强化技术的研究和临床操作方面的领导作用。从这段支持期开始，我们计划使用 RFA-RR-10-008 中所述的 G-MARC 对 CBRR 内的所有黑猩猩进行分类。通过扩大和提高 CBRR 资源的可用性、开展与资源相关的研究以及控制成本，CBRR 将继续提供极其重要、高度专业化的研究资源，以满足人类健康需求。

项目成果

期刊论文数量（57）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Male chimpanzees' grooming rates vary by female age, parity, and fertility status.

DOI：
10.1002/ajp.20964
发表时间：
2011-10
期刊：
AMERICAN JOURNAL OF PRIMATOLOGY
影响因子：
2.4
作者：
Proctor, Darby P.;Lambeth, Susan P.;Schapiro, Steven J.;Brosnan, Sarah F.
通讯作者：
Brosnan, Sarah F.

Chimpanzees copy dominant and knowledgeable individuals: implications for cultural diversity.

DOI：
10.1016/j.evolhumbehav.2014.09.002
发表时间：
2015-01
期刊：
Evolution and human behavior : official journal of the Human Behavior and Evolution Society
影响因子：
0
作者：
Kendal R;Hopper LM;Whiten A;Brosnan SF;Lambeth SP;Schapiro SJ;Hoppitt W
通讯作者：
Hoppitt W

Contrast of hemispheric lateralization for oro-facial movements between learned attention-getting sounds and species-typical vocalizations in chimpanzees: extension in a second colony.

黑猩猩习得的引起注意的声音与物种典型发声之间口面部运动的半球侧化对比：第二个群体的延伸。

DOI：
10.1016/j.bandl.2012.07.002
发表时间：
2012
期刊：
Brain and language
影响因子：
2.5
作者：
Wallez,Catherine;Schaeffer,Jennifer;Meguerditchian,Adrien;Vauclair,Jacques;Schapiro,StevenJ;Hopkins,WilliamD
通讯作者：
Hopkins,WilliamD

Pollical oblique ligament in humans and non-human primates.

人类和非人类灵长类动物的拇斜韧带。