Chimpanzee Biomedical Research Resource

描述（由申请人提供）：这是一份支持德克萨斯州巴斯托普德克萨斯大学MD安德森癌症中心迈克尔·e·基林比较医学与研究中心（KCCMR）“黑猩猩生物医学研究资源”（CBRR）合作协议的竞争性更新申请。CBRR是KCCMR黑猩猩住宅综合体内159只黑猩猩的国家研究资源。CBRR是世界上仅有的四个能够对该物种进行生物医学研究的研究资源之一。在过去的35年里，CBRR开发了高度专业化的住房设施、实验室、管理技术和工作人员，这些都是维持黑猩猩和使用这一重要模型进行研究所必需的。CBRR的主要目标仍然集中在群体的照顾和维护，为需要接触黑猩猩的研究人员提供进行研究所需的基础设施，以及开展研究以提高黑猩猩的研究价值。在目前的资助期内，我们开发了一个信息网站，以帮助科学家评估黑猩猩作为相关研究模型的适用性，并告知公众黑猩猩的价值。我们计划继续通过黑猩猩实验工具和实验室参考值登记处提供黑猩猩衍生的细胞系、抗体和其他生物材料。CBRR被组织成三个功能核心，包括资源管理核心、行为管理核心和资源相关研究核心。由CBRR支持的研究将继续强调黑猩猩免疫系统的特征以及通过行为管理核心进行的众多合作行为研究。这些研究包括对经过训练自愿配合研究程序的黑猩猩和未经训练必须被麻醉的黑猩猩进行对比的研究操作的生理和免疫后果。CBRR将继续在训练黑猩猩自愿参与使用正强化技术的研究和临床操作方面保持其领导作用。从这个支持期开始，我们计划使用RFA-RR-10-008中描述的G-MARC对CBRR内的所有黑猩猩进行分类。通过扩大和改善CBRR资源的可用性，开展与资源有关的研究，并控制成本，CBRR将继续提供一种极其重要的、高度专业化的研究资源，以满足人类健康需求。

DESCRIPTION (provided by applicant): This is a competing renewal application of a cooperative agreement supporting the "Chimpanzee Biomedical Research Resource" (CBRR) at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The University of Texas MD Anderson Cancer Center in Bastrop, TX. The CBRR is a national research resource of 159 chimpanzees housed within the chimpanzee housing complex of the KCCMR. The CBRR is one of only four research resources in the world capable of conducting biomedical research in this species. Over the past 35 years, the CBRR has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for maintaining chimpanzees and conducting research using this important model. The CBRR's primary objectives continue to focus on colony care and maintenance, provision of the infrastructure needed to conduct studies for investigators who need to access chimpanzees, and conducting studies to enhance the research value of chimpanzees. During the current funding period, we developed an informational website to help scientists assess the suitability of chimpanzees as relevant models for their studies and inform the public of the value of chimpanzees. We plan to continue to make available chimpanzee-derived cell lines, antibodies and other biological materials through the Chimpanzee Experimental Tools and Laboratory Reference Value Registry. The CBRR is organized into three functional cores that include the Resource Management Core, the Behavioral Management Core, and the Resource-related Research Core. Studies supported by the CBRR will continue to emphasize the characterization of the chimpanzee immune system and the numerous collaborative behavioral studies through the Behavioral Management Core. These include studies of the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures compared to untrained chimpanzees that must be anesthetized. The CBRR will continue to maintain its leadership role in the training of chimpanzees to voluntarily participate in research and clinical manipulations using positive reinforcement techniques. Beginning with this period of support, we plan to categorize all chimpanzees within the CBRR using the G-MARC as described in the RFA-RR-10-008. By expanding and improving the availability of CBRR resources, conducting resource-related research, and containing costs, the CBRR will continue to provide a critically important, highly specialized, research resource that addresses human health needs.