Shotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's Diseases

阿尔茨海默病中的鸟枪脂质组学和鞘脂组的改变

• 批准号: 8213595
• 负责人: Xianlin Han
• 金额: $ 66.28万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213595
• 关键词: Acyl Coenzyme A; Address; Aging; Alzheimer' s Disease; Biochemical; Biochemical Pathway; Bioinformatics; Biological Markers; Brain; Brain region; Cell Death; Ceramides; Cerebrospinal Fluid; Complex; Data; Development; Diabetes Mellitus; Disease; Early Diagnosis; Ethanolamines; Event; Fingerprint; Foundations; Functional disorder; Gangliosides; Glycerophospholipids; Human; Individual; Lactosylceramides; Link; Lipids; Maps; Mass Spectrum Analysis; Metabolic Pathway; Methods; Minor; Molecular; Multivariate Analysis; Myelin; Nerve Degeneration; Obesity; Pathogenesis; Pathology; Pathway interactions; Pharmaceutical Preparations; Play; Process; Psychosine; Reproducibility; Research; Research Personnel; Role; Sampling; Severities; Shotguns; Solid; Sphingolipids; Sphingosine; Staging; Structure; Sulfoglycosphingolipids; Synapses; Technology; Tissues; analog; base; brain tissue; ceramide 1-phosphate; computerized data processing; gray matter; human tissue; insight; interest; knockout gene; lipid metabolism; metabolomics; novel; novel therapeutic intervention; programs; sphingosine phosphorylcholine; white matter

项目成果

Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides.

• DOI: 10.1016/j.cmet.2013.12.016
• 发表时间: 2014-02-04
• 期刊: Cell metabolism
• 影响因子: 29
• 作者: Adamovich Y;Rousso-Noori L;Zwighaft Z;Neufeld-Cohen A;Golik M;Kraut-Cohen J;Wang M;Han X;Asher G
• 通讯作者: Asher G

Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach.

• DOI: 10.1021/ac402078p
• 发表时间: 2013-10-01
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Wang, Miao;Han, Rowland H.;Han, Xianlin
• 通讯作者: Han, Xianlin

Examination of the brain mitochondrial lipidome using shotgun lipidomics.

• DOI: 10.1007/978-1-60761-322-0_1
• 发表时间: 2009
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Kiebish, Michael A;Han, Xianlin;Seyfried, Thomas N
• 通讯作者: Seyfried, Thomas N

Multidimensional mass spectrometry-based shotgun lipidomics.

基于多维质谱的鸟枪脂质组学。

• DOI: 10.1007/978-1-4939-1258-2_13
• 发表时间: 2014
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Wang,Miao;Han,Xianlin
• 通讯作者: Han,Xianlin

Accurate quantification of lipid species by electrospray ionization mass spectrometry - Meet a key challenge in lipidomics.

• DOI: 10.3390/metabo1010021
• 发表时间: 2011-12-01
• 期刊: Metabolites
• 影响因子: 4.1
• 作者: Yang K;Han X
• 通讯作者: Han X