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Label free imaging of blood smears and tissue biopsies

血涂片和组织活检的无标记成像

基本信息

批准号：
8058667
负责人：
Gabriel Popescu
金额：
$ 14.21万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-08 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8058667
关键词：
Benign Biopsy Blood Breast Bypass Caliber Cells Code Complete Blood Count Computer software Data Data Analyses Databases Development Diagnosis Disease Ductal Carcinoma Dysmyelopoietic Syndromes Erythrocytes Folate Gleason Grade for Prostate Cancer Histology Hour Image Interference Microscopy Iron deficiency anemia Label Light Lobectomy Lung Macrocytic Anemia Malignant - descriptor Malignant Neoplasms Mastectomy Methodology Modification Myeloproliferative disease Optics Pathologist Polycythemia Vera Preparation Process Property Prostate Prostate carcinoma Radical Prostatectomy Refractive Indices Refractory Anemia with Ringed Sideroblasts Sampling Scanning Specimen Squamous Cell Lung Carcinoma Staging Staining method Stains System Techniques Tissues breast lumpectomy cancer type clinically relevant design improved infiltrating duct carcinoma instrumentation malignant breast neoplasm mean corpuscular volume observed microcytic anemia nanoscale

项目摘要

DESCRIPTION (provided by applicant): This exploratory project is aimed at investigating the potential of newly developed optical interferometric technique that we developed- Spatial Light Interference Microscopy (SLIM)-- for characterizing blood smears and tissue biopsies. SLIM is label-free and uniquely sensitive to refractive index modifications brought to the biospecimen by disease development . If successful, in the long-run, i.e. 5-10 years period, we anticipate that this label-free approach to imaging biospecimens will provide faster access to clinically-relevant data, as it bypasses most of the histology preparation process, e.g. staining. Further, due to its exquisite sensitivity to structural changes in the tissue, SLIM will provide a greater wealth of information than common histology, which should aid the pathologist in reaching a faster, more accurate diagnosis. The exploratory stage project will have the following specific aims: develop advanced, high-throughput instrumentation, perform proof-of principle studies on blood smears with focus on several specific diseases, and image biopsies of normal and three types of cancers (breast, prostate, and lung).

描述（由申请人提供）：本探索性项目旨在研究我们开发的新开发的光学干涉技术的潜力-空间光干涉显微镜(SLIM)-用于表征血液涂片和组织活检。SLIM是无标签的，对疾病发展给生物标本带来的折射率变化具有独特的敏感性。如果成功，从长远来看，即5-10年，我们预计这种无标签的生物标本成像方法将提供更快的临床相关数据，因为它绕过了大多数组织学准备过程，例如染色。此外，由于其对组织结构变化的敏感性，SLIM将提供比普通组织学更丰富的信息，这将有助于病理学家更快，更准确地诊断。探索性阶段项目将有以下具体目标：开发先进的高通量仪器，对几种特定疾病的血液涂片进行原理验证研究，以及对正常癌症和三种类型的癌症（乳腺癌、前列腺癌和肺癌）进行图像活检。