Mind-Body Interactions in Neuro-Oncology Family Caregivers

神经肿瘤家庭护理人员的身心互动

• 批准号: 8118960
• 负责人: Paula R Sherwood
• 金额: $ 37.64万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-14 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8118960
• 关键词: Address; Affect; Anxiety; Area; Behavioral; Biological; Biological Markers; Blood Pressure; Caregiver Burden; Caregivers; Caring; Characteristics; Chronic Disease; Data; Dementia; Diagnosis; Disease; Distress; Emotional; Endocrine; Energy Metabolism; Face; Family Caregiver; Family member; Functional disorder; Growth; Health; Health Personnel; Health Sciences; Heart Rate; Hypertension; Immune; Institutionalization; Interleukin-6; Intervention; Lead; Linear Regressions; Logistic Regressions; Malignant Neoplasms; Malignant neoplasm of brain; Measures; Mediating; Modeling; Morbidity - disease rate; Neurologic; Neurologic Dysfunctions; Neurotic Disorders; Occupational; Pattern; Persons; Population; Population Research; Public Health; Quality of Care; Quality of life; Regression Analysis; Research; Research Personnel; Risk; Sleep; Sleep disturbances; Social Obligations; Stress; Time; United States; Work; body-mind; burnout; care delivery; depressive symptoms; disease characteristic; experience; falls; improved; longitudinal design; loved ones; meetings; mind body interaction; mortality; multidisciplinary; neuro-oncology; outcome forecast; physical conditioning; prevent; programs; psychologic; response; satisfaction; social

DESCRIPTION (provided by applicant): Persons with a primary malignant brain tumor (PMBT) often suffer significant functional and neurologic morbidity causing family caregivers to assume the care recipient's familial, social, and financial obligations. Research has shown that caregivers of persons with other chronic diseases develop negative consequences as a result of providing care. Despite high morbidity (and mortality) rates for persons with a PMBT, caregiver issues in neuro-oncology have been virtually ignored. In response to PA-05-027, the purposes of this study are to use a multidisciplinary, integrative model, the Pittsburgh Mind Body Center Model, to (1) examine the psycho-behavioral responses (i.e. depressive symptoms and sleep), biologic responses (i.e. blood pressure and ihterleukins) and overall physical health of family members of persons with a PMBT at the time of diagnosis, and (2) to describe how relationships within the model vary over time in response to changes in the care recipient's illness trajectory as the family member transitions to a family caregiver. The specific aims of the project are to: 1) examine how care recipients' disease characteristics and caregivers' psycho- behavioral responses, biologic responses, and overall physical health change over time (from PBMT diagnosis to 12 months after diagnosis); and during this 12-month period, to 2) examine how caregivers' personal characteristics moderate the relationship between care recipients' disease characteristics and caregivers' psycho-behavioral responses; 3) examine how caregiver psycho-behavioral responses mediate the relationship between care recipients' disease characteristics and caregivers' biologic responses; and 4) examine how caregivers' biologic responses mediate the relationship between their psycho-behavioral responses and overall physical health. A descriptive longitudinal design will be used to collect data to address the aims of the project. Linear and logistic regression analysis will be used to model baseline responses. Repeated measures analysis (random coefficients modeling) will be used to examine change over time and latent growth curve modeling will be used to further explore longitudinal data. The relevance of the project to public health is to identify caregivers at specific time-points during the care recipient's disease trajectory who are vulnerable to changes in their emotional and physical health. Improving caregivers' emotional and physical health may improve the delivery of care and quality of life for the care recipient.

描述（由申请人提供）：患有原发性恶性脑肿瘤（PMBT）的人通常患有显著的功能和神经系统疾病，导致家庭护理人员承担护理接受者的家庭，社会和经济义务。研究表明，其他慢性病患者的照料者因提供照料而产生负面后果。尽管PMBT患者的发病率（和死亡率）很高，但神经肿瘤学中的护理人员问题几乎被忽视了。针对PA-05 - 027，本研究的目的是使用多学科的综合模型，匹兹堡身心中心模型，以（1）检查心理行为反应（即抑郁症状和睡眠），生物反应（即血压和白细胞介素）和PMBT患者家庭成员在诊断时的整体身体健康，以及（2）描述在家庭成员转变为家庭护理者时，模型内的关系如何响应于护理接受者的疾病轨迹的变化而随时间变化。本研究的具体目的是：1）研究受照顾者的疾病特征和照顾者的心理行为反应、生物反应和整体身体健康状况如何随时间变化。（从PBMT诊断到诊断后12个月）;在这12个月里，2）研究照顾者的个人特征如何调节照顾者的疾病特征和照顾者的心理特征之间的关系，行为反应; 3）研究照顾者的心理行为反应如何调节照顾者的疾病特征和照顾者的生物反应之间的关系;以及4）研究照顾者的生物反应如何调节他们的心理行为反应和整体身体健康之间的关系。描述性纵向设计将用于收集数据，以解决该项目的目标。将使用线性和逻辑回归分析对基线应答进行建模。重复测量分析（随机系数建模）将用于检查随时间的变化，潜在生长曲线建模将用于进一步探索纵向数据。该项目与公共卫生的相关性在于，在受照料者的疾病轨迹中的特定时间点，查明易受其情绪和身体健康变化影响的照料者。改善照顾者的情绪和身体健康可以改善护理的提供和护理接受者的生活质量。

项目成果

Exploring spirituality in family caregivers of patients with primary malignant brain tumors across the disease trajectory.

• DOI: 10.1188/13.onf.e119-e125
• 发表时间: 2013-05-01
• 期刊: Oncology nursing forum
• 影响因子: 1.9
• 作者: Newberry, Alyssa G;Choi, Chien-Wen Jean;Sherwood, Paula
• 通讯作者: Sherwood, Paula

Symptoms as the Main Predictors of Caregivers' Perception of the Suffering of Patients With Primary Malignant Brain Tumors.

症状是护理人员对原发性恶性脑肿瘤患者痛苦感知的主要预测因素。

• DOI: 10.1097/ncc.0000000000000261
• 发表时间: 2016
• 期刊: Cancer nursing
• 影响因子: 2.6
• 作者: Zeleníková,Renáta;Ren,Dianxu;Schulz,Richard;Given,Barbara;Sherwood,PaulaR
• 通讯作者: Sherwood,PaulaR

Family caregivers' level of mastery predicts survival of patients with glioblastoma: A preliminary report.

• DOI: 10.1002/cncr.30428
• 发表时间: 2017-03-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Boele FW;Given CW;Given BA;Donovan HS;Schulz R;Weimer JM;Drappatz J;Lieberman FS;Sherwood PR
• 通讯作者: Sherwood PR

Group-based trajectory modeling of caregiver psychological distress over time.

• DOI: 10.1007/s12160-012-9371-8
• 发表时间: 2012-08
• 期刊: ANNALS OF BEHAVIORAL MEDICINE
• 影响因子: 3.8
• 作者: Choi, Chien-Wen J.;Stone, Roslyn A.;Kim, Kevin H.;Ren, Dianxu;Schulz, Richard;Given, Charles W.;Given, Barbara A.;Sherwood, Paula R.
• 通讯作者: Sherwood, Paula R.

Sleep characteristics of family caregivers of individuals with a primary malignant brain tumor.

• DOI: 10.1188/13.onf.171-179
• 发表时间: 2013-03
• 期刊: Oncology nursing forum
• 影响因子: 1.9
• 作者: Pawl JD;Lee SY;Clark PC;Sherwood PR
• 通讯作者: Sherwood PR