Mind-Body Interactions in Neuro-Oncology Family Caregivers

神经肿瘤家庭护理人员的身心互动

• 批准号: 7675325
• 负责人: Paula R Sherwood
• 金额: $ 39.68万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-14 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7675325
• 关键词: Address; Affect; Anxiety; Area; Behavioral; Biological; Biological Markers; Blood Pressure; Caregiver Burden; Caregivers; Caring; Characteristics; Chronic Disease; Data; Dementia; Diagnosis; Disease; Distress; Emotional; Endocrine; Energy Metabolism; Face; Family Caregiver; Family member; Functional disorder; Growth; Health; Health Personnel; Health Sciences; Heart Rate; Hypertension; Immune; Institutionalization; Interleukin-6; Intervention; Lead; Logistic Regressions; Malignant Neoplasms; Malignant neoplasm of brain; Measures; Mediating; Modeling; Morbidity - disease rate; Neurologic; Neurologic Dysfunctions; Neurotic Disorders; Occupational; Pattern; Persons; Population; Population Research; Primary Brain Neoplasms; Public Health; Quality of Care; Quality of life; Regression Analysis; Research; Research Personnel; Risk; Sleep; Sleep disturbances; Social Obligations; Stress; Time; United States; Work; body-mind; burnout; care delivery; depressive symptoms; disease characteristic; experience; falls; improved; longitudinal design; loved ones; meetings; mind body interaction; mortality; multidisciplinary; neuro-oncology; outcome forecast; physical conditioning; prevent; programs; psychologic; response; satisfaction; social

DESCRIPTION (provided by applicant): Persons with a primary malignant brain tumor (PMBT) often suffer significant functional and neurologic morbidity causing family caregivers to assume the care recipient's familial, social, and financial obligations. Research has shown that caregivers of persons with other chronic diseases develop negative consequences as a result of providing care. Despite high morbidity (and mortality) rates for persons with a PMBT, caregiver issues in neuro-oncology have been virtually ignored. In response to PA-05-027, the purposes of this study are to use a multidisciplinary, integrative model, the Pittsburgh Mind Body Center Model, to (1) examine the psycho-behavioral responses (i.e. depressive symptoms and sleep), biologic responses (i.e. blood pressure and ihterleukins) and overall physical health of family members of persons with a PMBT at the time of diagnosis, and (2) to describe how relationships within the model vary over time in response to changes in the care recipient's illness trajectory as the family member transitions to a family caregiver. The specific aims of the project are to: 1) examine how care recipients' disease characteristics and caregivers' psycho- behavioral responses, biologic responses, and overall physical health change over time (from PBMT diagnosis to 12 months after diagnosis); and during this 12-month period, to 2) examine how caregivers' personal characteristics moderate the relationship between care recipients' disease characteristics and caregivers' psycho-behavioral responses; 3) examine how caregiver psycho-behavioral responses mediate the relationship between care recipients' disease characteristics and caregivers' biologic responses; and 4) examine how caregivers' biologic responses mediate the relationship between their psycho-behavioral responses and overall physical health. A descriptive longitudinal design will be used to collect data to address the aims of the project. Linear and logistic regression analysis will be used to model baseline responses. Repeated measures analysis (random coefficients modeling) will be used to examine change over time and latent growth curve modeling will be used to further explore longitudinal data. The relevance of the project to public health is to identify caregivers at specific time-points during the care recipient's disease trajectory who are vulnerable to changes in their emotional and physical health. Improving caregivers' emotional and physical health may improve the delivery of care and quality of life for the care recipient.

描述（由申请人提供）：患有原发性恶性脑肿瘤（PMBT）的人通常会遭受严重的功能和神经系统疾病，导致家庭护理人员承担护理接受者的家庭、社会和经济义务。研究表明，其他慢性病患者的护理人员因提供护理而产生负面后果。尽管 PMBT 患者的发病率（和死亡率）很高，但神经肿瘤学中的护理人员问题实际上被忽视了。针对 PA-05-027，本研究的目的是使用多学科综合模型，即匹兹堡身心中心模型，(1) 检查 PMBT 患者在诊断时的心理行为反应（即抑郁症状和睡眠）、生物反应（即血压和白细胞介素）和整体身体健康状况，以及 (2) 描述 当家庭成员转变为家庭照顾者时，模型内的关系如何随着时间的推移而变化，以响应被照顾者的疾病轨迹的变化。该项目的具体目标是： 1) 检查护理对象的疾病特征和护理人员的心理行为反应、生物反应和整体身体健康如何随时间变化（从 PBMT 诊断到诊断后 12 个月）；在这 12 个月期间，2) 检查护理人员的个人特征如何调节护理接受者的疾病特征和护理人员的心理行为反应之间的关系； 3）检查护理人员的心理行为反应如何调节护理接受者的疾病特征和护理人员的生物反应之间的关系； 4) 研究护理人员的生物反应如何调节其心理行为反应与整体身体健康之间的关系。将使用描述性纵向设计来收集数据以实现项目的目标。线性和逻辑回归分析将用于对基线响应进行建模。重复测量分析（随机系数建模）将用于检查随时间的变化，潜在增长曲线建模将用于进一步探索纵向数据。该项目与公共卫生的相关性是确定在护理接受者疾病轨迹的特定时间点易受情绪和身体健康变化影响的护理人员。改善护理人员的情绪和身体健康可以改善护理服务的提供和护理接受者的生活质量。