课题基金 / 基金详情

MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO

MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO
体外机械引导泌尿组织再生
批准号:
8360199
负责人:
JIRO NAGATOMI
金额:
$11.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-06-01 至 2012-05-31

项目摘要

项目成果

JIRO NAGATOMI的其他基金

相似基金

相关文献

中文摘要
翻译
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Recent clinical success in bladder tissue engineering demonstrated the feasibility of this technology to combine synthetic polymer scaffolds with host cells for bladder reconstruction. Yet, there remain several unresolved issues. For example, in-vitro culturing of bladder smooth muscle cells for a prolonged time period results in de-differentiation and loss of the contractile phenotype of these cells. Our group previously demonstrated that 3D cultures of bladder SMCs subjected to sustained tension exhibited significantly greater levels of contractile phenotype markers compared to the no-tension control. We hypothesize that exposure of 3D culture of bladder SMCs to appropriate mechanical stimuli leads to guided cell growth and retention of contractile phenotype. The long-term objective of the present study is to develop both biomaterials and a bioreactor system that guide SMC growth for use in the tissue engineering applications.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of Scar-Inhibiting Compliant Tissue Adhesive
  • 批准号:
    7789558
  • 项目类别:
  • 资助金额:
    $21.44万
  • 财政年份:
    2010
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
Development of Scar-Inhibiting Compliant Tissue Adhesive
  • 批准号:
    8013938
  • 项目类别:
  • 资助金额:
    $17.0万
  • 财政年份:
    2010
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO
  • 批准号:
    8168474
  • 项目类别:
  • 资助金额:
    $5.78万
  • 财政年份:
    2010
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
海外基金