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MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO

MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO
体外机械引导泌尿组织再生
批准号:
8168474
负责人:
JIRO NAGATOMI
金额:
$5.78万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-06-01 至 2011-05-31

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项目成果

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent clinical success in bladder tissue engineering by Atala el al (1) demonstrated the feasibility of this technology to combine synthetic polymer scaffolds with host cells for bladder reconstruction. Yet, there remain several unresolved issues. For example, in-vitro culturing of bladder smooth muscle cells for a prolonged time period results in de-differentiation and loss of the contractile phenotype of these cells. Our group previously demonstrated that 3D cultures of bladder SMCs subjected to sustained tension exhibited significantly greater levels of contractile phenotype markers compared to the no-tension control (2). We hypothesize that exposure of 3D culture of bladder SMCs to appropriate mechanical stimuli leads to guided cell growth and retention of contractile phenotype. The long-term objective of the present study is to develop both biomaterials and a bioreactor system that guide SMC growth for use in the tissue engineering applications.
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MECHANICALLY GUIDED UROLOGICAL TISSUE REGENERATION IN VITRO
  • 批准号:
    8360199
  • 项目类别:
  • 资助金额:
    $11.18万
  • 财政年份:
    2011
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
Development of Scar-Inhibiting Compliant Tissue Adhesive
  • 批准号:
    7789558
  • 项目类别:
  • 资助金额:
    $21.44万
  • 财政年份:
    2010
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
Development of Scar-Inhibiting Compliant Tissue Adhesive
  • 批准号:
    8013938
  • 项目类别:
  • 资助金额:
    $17.0万
  • 财政年份:
    2010
  • 负责人:
    JIRO NAGATOMI
  • 依托单位:
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