20-year intergenerational longitudinal followup of females abused as children

描述(申请人提供)：少数纵向队列跨越多个发育阶段，并跨越世代。个人资料调查成功地挽留了96%曾经历过儿童期性虐待的女性样本(N=84名)和一名人口统计学上相似的对照组(N=89名)20年；在童年/青春期早期完成了三次全面的生物心理评估(T1-T3)，在青春期后期/成年初期完成了两次(T4和T5)，在青年时期(T6)完成了一次。我们还评估了样本(N=135)所生的所有已知后代的91%。到目前为止所产生的结果对有关虐待对女性发育的影响的长期后遗症和代际转移的文献有很大贡献。额外的后续评估(T7)将采用新技术(包括远程网络和基于PC的评估工具)和新兴理论模型(包括风险和复原力的基因X环境和荷尔蒙模型)，这将使我们能够做出更多贡献。然而，为了产生针对T7后续行动的最具竞争力的R01，我们必须首先确定试行新出现的创新方法的可行性，并从样本中确定他们可以/将参与的方式以及目前构成的后代样本的人口构成。此外，这是一个特别脆弱的群体，因此我们花时间仔细而敏感地将新兴技术(特别是遗传学)整合到我们的方案中是至关重要的。因此，这项申请寻求开发创新方法和新技术，以促进发展研究，并建议评估利用这些技术完成对儿童期虐待对女性发展的影响的最长、持续研究的20年跟踪的可行性。这项可行性研究将为高度创新、具有竞争力的R01奠定基础，旨在测试儿童时期遭受虐待的女性及其家庭在整个发展过程中和跨代受虐待的全面基因X环境和生物-心理-社会模型。 公共卫生相关性：这是一项可行性研究，旨在定位和重新联系参与一项为期20年的纵向研究的家庭，以确定人口统计更新和参与第七波研究的意愿。一部分家庭将接受新技术的试验性测试，包括使用辅助专业人员进行生物采样(包括基因采样)，以及对成年参与者及其子女进行远程网络和基于计算机的评估程序。这项研究将为高度创新、具有竞争力的R01奠定基础，旨在测试复杂的多变量心理社会、遗传易感性、基因-环境交互作用，以及在整个发育过程中和跨代受虐待的女性及其家庭的风险和弹性的生物行为模型。

DESCRIPTION (provided by applicant): Few longitudinal cohorts span multiple developmental stages and extend across generations. The PIs have been successful at retaining 96% of a sample of females who experienced substantiated childhood sexual abuse (N=84) and a demographically similar comparison group (N=89) for 20 years; accomplishing comprehensive bio-psychological assessments three times (T1-T3) in childhood/early adolescence, twice (T4 & T5) in later adolescence/emerging adulthood, and once in young adulthood (T6). We have also assessed 91% of all known offspring born to the sample (N=135). Results generated thus far have contributed substantially to the literature on the long-term sequelae and intergenerational transference of the effects of abuse on female development. An additional followup assessment (T7) which would employ new technologies (including remote web and PC-based assessment tools) and emerging theoretical models (including geneXenvironment and hormone models of risk and resilience) will allow us to contribute much, much more. However, in order to produce the most competitive R01 aimed at a T7 followup, we must first establish feasibility in piloting emergent, innovative methodologies and ascertain from the sample both the ways in which they can/will participate and the demographic make up of the offspring sample as it is now comprised. Further, this is a particularly vulnerable population so it is vitally important that we take the time to carefully and sensitively integrate emerging technologies (genetics in particular) into our protocols. Hence, this application seeks to develop innovative methodologies and new technology to advance developmental research and proposes to evaluate the feasibility of utilizing these techniques to accomplish the 20-year followup of the longest, ongoing study of the impact of childhood abuse on female development. This feasibility study will set the stage for a highly innovative, competitive R01 aimed at testing comprehensive geneXenvironment and bio- psycho-social models of risk and resilience throughout development and across generations for females abused in childhood and their families. PUBLIC HEALTH RELEVANCE: This is a feasibility study to locate and recontact families participating in a 20-year longitudinal study to ascertain demographic updates and willingness to participate in a 7th wave. A subset of families will undergo pilot testing of new technologies including the use of para-professionals for biological sampling (including genetic sampling) and remote web and PC-based assessment procedures for adult participants and their offspring. The study will set the stage for a highly innovative, competitive R01 aimed at testing complex multivariate psychosocial, genetic predisposition, gene-environment interaction, and biobehavioral models of risk and resilience throughout development and across generations for females abused in childhood and their families.