20-year intergenerational longitudinal followup of females abused as children

描述（由申请人提供）：很少有纵向队列跨越多个发育阶段并跨越几代人。PI成功地保留了96%的女性样本，这些女性经历了证实的儿童期性虐待（N=84）和人口统计学上相似的对照组（N=89）20年;在儿童期/青春期早期完成了三次全面的生物心理评估（T1-T3），在青春期后期/成年初显期完成了两次（T4和T5），在成年早期完成了一次（T6）。我们还评估了91%的已知样本后代（N=135）。迄今为止取得的成果为关于虐待对女性发展的影响的长期后遗症和代际转移的文献作出了重大贡献。一个额外的后续评估（T7）将采用新技术（包括远程网络和基于PC的评估工具）和新兴的理论模型（包括风险和复原力的基因环境和激素模型），这将使我们能够做出更多的贡献。然而，为了生产针对T7后续研究的最具竞争力的R 01，我们必须首先确定试点新兴创新方法的可行性，并从样本中确定他们可以/将参与的方式以及后代样本的人口构成，就像它现在的组成一样。此外，这是一个特别脆弱的人群，因此我们花时间仔细和敏感地将新兴技术（特别是遗传学）纳入我们的协议至关重要。因此，本申请旨在开发创新的方法和新技术，以推进发展研究，并建议评估利用这些技术来完成对儿童虐待对女性发展影响的最长持续研究的20年随访的可行性。这项可行性研究将为一项高度创新、具有竞争力的R 01奠定基础，该研究旨在测试儿童时期受虐待的女性及其家庭在整个发展过程中和跨代的风险和复原力的综合基因、环境和生物-心理-社会模型。 公共卫生相关性：这是一项可行性研究，目的是找到并重新联系参加20年纵向研究的家庭，以确定人口统计学最新情况和参加第七波的意愿。一部分家庭将接受新技术的试点测试，包括使用辅助专业人员进行生物采样（包括遗传采样），以及对成年参与者及其后代进行远程网络和个人电脑评估程序。该研究将为高度创新，具有竞争力的R 01奠定基础，旨在测试复杂的多变量心理社会，遗传易感性，基因-环境相互作用以及整个发展过程中的风险和弹性的生物行为模型，以及儿童时期受虐待的女性及其家庭的代际。

DESCRIPTION (provided by applicant): Few longitudinal cohorts span multiple developmental stages and extend across generations. The PIs have been successful at retaining 96% of a sample of females who experienced substantiated childhood sexual abuse (N=84) and a demographically similar comparison group (N=89) for 20 years; accomplishing comprehensive bio-psychological assessments three times (T1-T3) in childhood/early adolescence, twice (T4 & T5) in later adolescence/emerging adulthood, and once in young adulthood (T6). We have also assessed 91% of all known offspring born to the sample (N=135). Results generated thus far have contributed substantially to the literature on the long-term sequelae and intergenerational transference of the effects of abuse on female development. An additional followup assessment (T7) which would employ new technologies (including remote web and PC-based assessment tools) and emerging theoretical models (including geneXenvironment and hormone models of risk and resilience) will allow us to contribute much, much more. However, in order to produce the most competitive R01 aimed at a T7 followup, we must first establish feasibility in piloting emergent, innovative methodologies and ascertain from the sample both the ways in which they can/will participate and the demographic make up of the offspring sample as it is now comprised. Further, this is a particularly vulnerable population so it is vitally important that we take the time to carefully and sensitively integrate emerging technologies (genetics in particular) into our protocols. Hence, this application seeks to develop innovative methodologies and new technology to advance developmental research and proposes to evaluate the feasibility of utilizing these techniques to accomplish the 20-year followup of the longest, ongoing study of the impact of childhood abuse on female development. This feasibility study will set the stage for a highly innovative, competitive R01 aimed at testing comprehensive geneXenvironment and bio- psycho-social models of risk and resilience throughout development and across generations for females abused in childhood and their families. PUBLIC HEALTH RELEVANCE: This is a feasibility study to locate and recontact families participating in a 20-year longitudinal study to ascertain demographic updates and willingness to participate in a 7th wave. A subset of families will undergo pilot testing of new technologies including the use of para-professionals for biological sampling (including genetic sampling) and remote web and PC-based assessment procedures for adult participants and their offspring. The study will set the stage for a highly innovative, competitive R01 aimed at testing complex multivariate psychosocial, genetic predisposition, gene-environment interaction, and biobehavioral models of risk and resilience throughout development and across generations for females abused in childhood and their families.